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2′-O-Methyluridine is a modified nucleoside found in T. thermophile tRNA. Its serum level is decreased in breast cancer patients. It can be incorporated into siRNA targeting the gene encoding apolipoprotein B, which reduces ApoB protein levels in HepG2 and prevents IFN-α production in isolated human PBMCs.
Modified nucleoside
Found in T. thermophile tRNA
Decreased in serum levels in breast cancer patients
Used in siRNA targeting apolipoprotein B
Reduces ApoB protein levels
Prevents IFN-α production
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5-Azacytidine is an analog of the nucleoside cytidine which can be incorporated into DNA and RNA. 5-Azacytidine acts as an epigenetic modifier by incorporating into DNA where it irreversibly binds to DNA methyltransferases, thus inhibiting their activity. REPROGRAMMING· Increases reprogramming efficiency of mouse fibroblasts to induced pluripotent stem (iPS) cells by inducing full reprogramming of partially reprogrammed cells (Mikkelsen et al.).· Resets epigenetic memory in mouse iPS cells, in combination with Trichostatin A (Kim et al.). DIFFERENTIATION· Enhances differentiation to cardiomyocytes from human embryonic stem cells (Yoon et al.).CANCER RESEARCH· Wide range of anti-metabolic activities when tested against cultured cancer cells and an effective chemotherapeutic agent for acute myelogenous leukemia
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2'-C-methyluridine is a uridine nucleoside analog supplied as a white to off-white solid for laboratory research. It is used in biochemical and pharmacological studies of nucleoside analogs and as a reagent in enzymatic and antiviral assays.
Provides a uridine analog for nucleoside research.
High purity suitable for analytical and biochemical applications.
Soluble in water; may require ultrasonic agitation for complete dissolution.
Stable when stored as a powder under low-temperature conditions.
Available in small laboratory sizes for research workflows.
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Nucleoside-Analog-2 is a 4'-Azidocytidine analogue primarily designed to act against Hepatitis C virus (HCV) replication. It functions as a versatile click chemistry reagent, featuring an Azide group, which enables participation in both copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
Acts against hepatitis C virus (HCV) replication
Functions as a click chemistry reagent
Contains an azide group for CuAAc reactions with alkyne-containing molecules
Undergoes SPAAC reactions with DBCO or BCN group-containing molecules
Intended for research use only
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