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RMC-6236 is a First-in-Class, non-covalent, oral, potent, and RAS-Selective Tri-Complex RASMULTI(ON) Inhibitor with activity across a diverse spectrum of RAS mutants, including KRASG12V and KRASG12D (
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15N, heavy-labeled ubiquitin provides a stable standard for ubiquitin structural study by NMR. The recombinant human ubiquitin is purified from E. coli expressing the human ubiquitin gene. The cells are grown in media where the sole nitrogen source is 15N labeled ammonium sulfate. The recombinant human ubiquitin is purified without heating by a proprietary procedure that preserves the native structure of the protein. The purified protein is homogenous when analyzed by overloaded SDS gels. The pools of purified protein solution are extensively dialyzed against water and lyophilized.
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YG1702 is a potent ALDH18A1-specific inhibitor. YG1702 attenuates the growth of MYCN-amplified NB and down-regulates MYCN. YG1702 physically interacts with ALDH18A1 with a high affinity and might potentially affect its enzymatic activity.
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LAH5 is an amphipathic cell-penetrating peptide. LAH5 effectively delivers CRISPR-Cas9 components into the nuclei of target cells by forming nanocomplexes with both RNP and RNP/HDR cargo.
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