Isotype Controls and Standards
Roche Diagnostics Rabbit Monoclonal Negative Control Ig
Rabbit Monoclonal Negative Control Ig is intended for laboratory use as a control for nonspecific binding of rabbit immunoglobulin in sections of formalin-fixed, paraffin-embedded tissue when stained on VENTANA BenchMark IHC/ISH platforms (BenchMark GX, BenchMark XT, and BenchMark ULTRA). This product should be interpreted by a qualified pathologist in conjunction with histological examination, relevant clinical information, and proper controls. This product is intended for in vitro diagnostic (IVD) use.
Cayman Chemical Telotristat Etiprate, Purity: ≥98%, CAS: 1137608-69-5, 25 mg
A prodrug form of telotristat; reduces levels of 5-HT in mouse jejunum and blood at 15-300 mg/kg; inhibits increases in IL-1β and IL-6 levels, histological damage in the colon, and weight loss in a mouse model of trinitrobenzene sulfonic acid-induced colitis at 200 mg/kg; reduces colonic levels of MPO, IL-1β, and IL-17, as well as worm burden, in mice infected with T. muris at 300 mg/kg
Cayman Chemical Ganciclovir (sodium salt), Purity: ≥98%, CAS: 107910-75-8, 25 mg
An active metabolite of valganciclovir and an antiviral nucleoside derivative; reduces human, monkey, mouse, and guinea pig CMV replication in plaque reduction assays (EC50s = 1.3-70 µM); topical application decreases disease severity and corneal leukocyte infiltration in a cat model of ocular FHV-1 epithelial infection at 0.15%; prevents allograft histologic injury and NK and myeloid cell infiltration in a mouse model of murine CMV infection with renal transplantation at 15 mg/kg; induces tumor regression in a K-BALB murine sarcoma model using a mixed population of HSV TK positive or negative cells
Leinco Technologies Inc Anti-Mouse CD45 (T200, Ly-5, LCA) In Vivo PLATINUM; Clone I3/2.3; Isotype: Rat IgG2b
Specificity: Clone I3/2.3 recognizes an epitope on mouse CD45. Antigen Distribution: CD45 is expressed on all hematopoietic cells other than mature erythrocytes and platelets. Background: CD45 is a 180-240kD glycoprotein member of the PTP family that plays a key role in TCR and BCR signal transduction. CD45 also serves as a negative regulator of cytokine receptor signaling. Applications: (FC) Antibodies against the different isoforms of CD45 are used to distinguish between histological sections from lymphomas and carcinomas and, in immunohistochemistry, to differentiate between immune cell types. The use of Clone I3/2.3 for IHC-P and IHC-F has been reported in literature. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Leinco Technologies Inc Anti-Mouse CD45 (T200, Ly-5, LCA) In Vivo PLATINUM; Clone I3/2.3; Isotype: Rat IgG2b
Specificity: Clone I3/2.3 recognizes an epitope on mouse CD45. Antigen Distribution: CD45 is expressed on all hematopoietic cells other than mature erythrocytes and platelets. Background: CD45 is a 180-240kD glycoprotein member of the PTP family that plays a key role in TCR and BCR signal transduction. CD45 also serves as a negative regulator of cytokine receptor signaling. Applications: (FC) Antibodies against the different isoforms of CD45 are used to distinguish between histological sections from lymphomas and carcinomas and, in immunohistochemistry, to differentiate between immune cell types. The use of Clone I3/2.3 for IHC-P and IHC-F has been reported in literature. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Leinco Technologies Inc Anti-Mouse CD45 (T200, Ly-5, LCA) In Vivo PLATINUM; Clone I3/2.3; Isotype: Rat IgG2b
Specificity: Clone I3/2.3 recognizes an epitope on mouse CD45. Antigen Distribution: CD45 is expressed on all hematopoietic cells other than mature erythrocytes and platelets. Background: CD45 is a 180-240kD glycoprotein member of the PTP family that plays a key role in TCR and BCR signal transduction. CD45 also serves as a negative regulator of cytokine receptor signaling. Applications: (FC) Antibodies against the different isoforms of CD45 are used to distinguish between histological sections from lymphomas and carcinomas and, in immunohistochemistry, to differentiate between immune cell types. The use of Clone I3/2.3 for IHC-P and IHC-F has been reported in literature. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Leinco Technologies Inc Anti-Mouse CD45 (T200, Ly-5, LCA) In Vivo PLATINUM; Clone I3/2.3; Isotype: Rat IgG2b
Specificity: Clone I3/2.3 recognizes an epitope on mouse CD45. Antigen Distribution: CD45 is expressed on all hematopoietic cells other than mature erythrocytes and platelets. Background: CD45 is a 180-240kD glycoprotein member of the PTP family that plays a key role in TCR and BCR signal transduction. CD45 also serves as a negative regulator of cytokine receptor signaling. Applications: (FC) Antibodies against the different isoforms of CD45 are used to distinguish between histological sections from lymphomas and carcinomas and, in immunohistochemistry, to differentiate between immune cell types. The use of Clone I3/2.3 for IHC-P and IHC-F has been reported in literature. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Leinco Technologies Inc Anti-Human CD3 (T3, CD3ε) In Vivo PLATINUM; Clone UCHT-1; Isotype: Mouse IgG1
Specificity: Clone UCHT-1 binds to the human CD3ε-chain. Antigen Distribution: CD3 is expressed on human peripheral blood lymphocytes, splenic lymphocytes, the majority of T-CLL and T-ALL cells. Background: CD3ε is a T-cell surface glycoprotein and is a 20-kDa subunit of the TCR complex used for enumerating immunocompetent T-lymphocytes in peripheral blood. CD3 is involved in signal transduction during antigen recognition. Applications: (FC, IP, WB) Clone UCHT-1 is also useful in histology for localization of T-lymphocytes in tissue and may be used to enrich T-cells by cell sorting. This T-cell marker has also been used to determine T-versus B-cell lymphomas and leukemias. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Leinco Technologies Inc Anti-Human CD3 (T3, CD3ε) In Vivo PLATINUM; Clone UCHT-1; Isotype: Mouse IgG1
Specificity: Clone UCHT-1 binds to the human CD3ε-chain. Antigen Distribution: CD3 is expressed on human peripheral blood lymphocytes, splenic lymphocytes, the majority of T-CLL and T-ALL cells. Background: CD3ε is a T-cell surface glycoprotein and is a 20-kDa subunit of the TCR complex used for enumerating immunocompetent T-lymphocytes in peripheral blood. CD3 is involved in signal transduction during antigen recognition. Applications: (FC, IP, WB) Clone UCHT-1 is also useful in histology for localization of T-lymphocytes in tissue and may be used to enrich T-cells by cell sorting. This T-cell marker has also been used to determine T-versus B-cell lymphomas and leukemias. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Leinco Technologies Inc Anti-Human CD3 (T3, CD3ε) In Vivo PLATINUM; Clone UCHT-1; Isotype: Mouse IgG1
Specificity: Clone UCHT-1 binds to the human CD3ε-chain. Antigen Distribution: CD3 is expressed on human peripheral blood lymphocytes, splenic lymphocytes, the majority of T-CLL and T-ALL cells. Background: CD3ε is a T-cell surface glycoprotein and is a 20-kDa subunit of the TCR complex used for enumerating immunocompetent T-lymphocytes in peripheral blood. CD3 is involved in signal transduction during antigen recognition. Applications: (FC, IP, WB) Clone UCHT-1 is also useful in histology for localization of T-lymphocytes in tissue and may be used to enrich T-cells by cell sorting. This T-cell marker has also been used to determine T-versus B-cell lymphomas and leukemias. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Leinco Technologies Inc Anti-Human CD3 (T3, CD3ε) In Vivo PLATINUM; Clone UCHT-1; Isotype: Mouse IgG1
Specificity: Clone UCHT-1 binds to the human CD3ε-chain. Antigen Distribution: CD3 is expressed on human peripheral blood lymphocytes, splenic lymphocytes, the majority of T-CLL and T-ALL cells. Background: CD3ε is a T-cell surface glycoprotein and is a 20-kDa subunit of the TCR complex used for enumerating immunocompetent T-lymphocytes in peripheral blood. CD3 is involved in signal transduction during antigen recognition. Applications: (FC, IP, WB) Clone UCHT-1 is also useful in histology for localization of T-lymphocytes in tissue and may be used to enrich T-cells by cell sorting. This T-cell marker has also been used to determine T-versus B-cell lymphomas and leukemias. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Leinco Technologies Inc Anti-Human CD3 (T3, CD3ε) In Vivo GOLD; Clone UCHT-1; Isotype: Mouse IgG1
Specificity: Clone UCHT-1 binds to the human CD3ε-chain. Antigen Distribution: CD3 is expressed on human peripheral blood lymphocytes, splenic lymphocytes, the majority of T-CLL and T-ALL cells. Background: CD3ε is a T-cell surface glycoprotein and is a 20-kDa subunit of the TCR complex used for enumerating immunocompetent T-lymphocytes in peripheral blood. CD3 is involved in signal transduction during antigen recognition. Applications: (FC, IP, WB) Clone UCHT-1 is also useful in histology for localization of T-lymphocytes in tissue and may be used to enrich T-cells by cell sorting. This T-cell marker has also been used to determine T-versus B-cell lymphomas and leukemias. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Leinco Technologies Inc Anti-Human CD3 (T3, CD3ε) In Vivo GOLD; Clone UCHT-1; Isotype: Mouse IgG1
Specificity: Clone UCHT-1 binds to the human CD3ε-chain. Antigen Distribution: CD3 is expressed on human peripheral blood lymphocytes, splenic lymphocytes, the majority of T-CLL and T-ALL cells. Background: CD3ε is a T-cell surface glycoprotein and is a 20-kDa subunit of the TCR complex used for enumerating immunocompetent T-lymphocytes in peripheral blood. CD3 is involved in signal transduction during antigen recognition. Applications: (FC, IP, WB) Clone UCHT-1 is also useful in histology for localization of T-lymphocytes in tissue and may be used to enrich T-cells by cell sorting. This T-cell marker has also been used to determine T-versus B-cell lymphomas and leukemias. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Leinco Technologies Inc Anti-Human CD3 (T3, CD3ε) In Vivo GOLD; Clone UCHT-1; Isotype: Mouse IgG1
Specificity: Clone UCHT-1 binds to the human CD3ε-chain. Antigen Distribution: CD3 is expressed on human peripheral blood lymphocytes, splenic lymphocytes, the majority of T-CLL and T-ALL cells. Background: CD3ε is a T-cell surface glycoprotein and is a 20-kDa subunit of the TCR complex used for enumerating immunocompetent T-lymphocytes in peripheral blood. CD3 is involved in signal transduction during antigen recognition. Applications: (FC, IP, WB) Clone UCHT-1 is also useful in histology for localization of T-lymphocytes in tissue and may be used to enrich T-cells by cell sorting. This T-cell marker has also been used to determine T-versus B-cell lymphomas and leukemias. Leinco’s In vivo GOLDTM and In vivo PLATINUMTM functional antibodies are manufactured in an animal free facility using only In vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.