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VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. VRK1 is widely expressed in human tissues and actively dividing cells such as those in testis leukocytes fetal liver and carcinomas. VRK1 regulate cell proliferation and phosphorylates histone casein and the transcription factors ATf2 (activating transcription factor 2) and c-JUN. The spinal muscular atrophy with pontocerebellar hypoplasia is caused by a mutation in the VRK1 gene.
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A highly potent, reversible inhibitor of the EGFR (Ki = 5.2 pM; IC50 = 29 pM); rapidly suppresses autophosphorylation of EGFR in fibroblasts and human epidermoid carcinoma cells
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A prodrug form of furamidine reduces the number of circulating parasites and increases survival at 25 mg/kg per day in a mouse model of T. cruzi infection in combination with benznidazole
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A triacylglycerol; reduces serum cholesterol levels in rats; decreases plasma cholesterol levels and glutamyl transpeptidase activity, increases plasma LDL, HDL, and protein levels, and reduces diarrhea rate in weaned piglets when administered as 0.5% of the diet
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A triacylglycerol; dietary administration increases hepatic and adipose tissue G6PDH, CCE, and malic enzyme activities in rats at 260 g/kg; induces nuclear edema and cytolysis in tumor cells, but not normal hepatic cells, in a murine hepatic carcinoma model
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A diacylglycerol; has been used as an internal standard for the quantification of free fatty acids, monoacylglycerols, and diacylglycerols in the subcutaneous fat of raw and dry-cured Iberian ham
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A triacylglycerol; has been used as an internal standard for the quantification of fatty acids in the triglyceride component of HAECs grown in media supplemented with stearic and/or oleic acid
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