MW 378.4 Da, Purity >99%. A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist (IC₅₀ = 4 nM). Shows >2500-fold selectivity over CCR7, CXCR1, CXCR2, C4aR and LTD₄ receptors. Inhibits Ca²+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 (IC₅₀ values are 38, 35, and 20 nM, respectively). Also inhibits eosinophil chemotaxis.
The product is subject to the following: Abcam Restricted Use Statement