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Crosslinking Reagents

Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.

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1

Medchemexpress LLC Dbco-acid | 1353016-70-2 | MFCD28064336 | 99.7% | 305.33 g/mol | C19H15NO3 | 100 MG
SDP

Dbco-acid is a dibenzocyclooctyne carboxylic acid used as a click chemistry reagent for bioorthogonal conjugation and linker synthesis. It is supplied as a purified solid for research applications and for preparing DBCO-derived NHS esters and PEG conjugates.

  • Used for bioorthogonal click chemistry and linker synthesis.
  • High purity: 99.71%.
  • Molecular weight: 305.33 g/mol.
  • Chemical formula: C19H15NO3.
  • Available as 100 MG solid with accompanying datasheet and SDS.

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2

Medchemexpress LLC Lys-Nε-MCC-DM1 | 1281816-04-3 | 99.6% | 1103.71 g·mol⁻¹ | C53H75ClN6O15S | 5 MG
SDP

Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a linker-payload conjugate and active metabolite used in antibody-drug conjugate (ADC) research. It inhibits tubulin polymerization and is used for linker development, payload characterization, and in vitro pharmacology studies.

  • High purity (>99.6%) suitable for analytical work.
  • Molecular weight 1103.71 g·mol⁻¹.
  • Chemical formula C53H75ClN6O15S.
  • Inhibits tubulin polymerization for mechanism studies.
  • Intended for ADC linker-payload and metabolite research.
  • Provided as a solid convenient for storage and handling.

ENCOMPASS_PREFERRED
3

Medchemexpress LLC 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate | 874302-76-8 | MFCD28556879 | 99.6% | 352.39 g/mol | C14H12N2O5S2 | 5 G
SDP

PDEC-NB is a disulfide-cleavable linker used for the synthesis of antibody-drug conjugates (ADCs). It releases payloads under reducing intracellular conditions via a pyridinyl-disulfide-triggered mechanism. Supplied as a white to off-white solid for research use only.

  • Used as a disulfide cleavable linker for ADC synthesis.
  • Molecular weight 352.39 g/mol.
  • Chemical formula C14H12N2O5S2.
  • CAS number 874302-76-8.
  • Appearance white to off-white solid.
  • For research use only; not for human use.

ENCOMPASS_PREFERRED
4

Medchemexpress LLC SPDP-PEG4-NHS ester | 1334177-95-5 | 95.0% | 25 MG
SDP

SPDP-PEG4-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It has a molecular weight of 559.65, a chemical formula of C23H33N3O9S2, and appears as a colorless to light yellow liquid.

  • PEG-based PROTAC linker
  • Used in PROTAC synthesis
  • Contains two different ligands connected by a linker
  • Targets an E3 ubiquitin ligase and a protein of interest
  • Utilizes the intracellular ubiquitin-proteasome system
  • Selectively degrades target proteins

ENCOMPASS_PREFERRED
5

Medchemexpress LLC Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt | 185332-92-7 | MFCD17215919 | 98.8% | 382.28 g/mol | C12H11N2NaO9S | 5 MG
SDP

Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt is a water-soluble, heterobifunctional cross-linker used to couple primary amines to sulfhydryl groups in proteins and peptides. It is designed for aqueous bioconjugation and chemical modification workflows where selective amine-to-thiol linking is required.

  • Water soluble heterobifunctional cross-linker suitable for aqueous reactions.
  • Selective amine-to-thiol coupling for targeted bioconjugation.
  • High reported purity for reliable reaction performance.
  • Soluble in DMSO at approximately 50 mg/mL for stock preparation.
  • Available in small pack sizes for research and development use.

ENCOMPASS_PREFERRED
6

Medchemexpress LLC N3-C4-NHS ester | 478801-48-8 | 99.5% | 240.22 g/mol | C9H12N4O4 | 250 MG
SDP

N3-C4-NHS ester is a noncleavable antibody-drug conjugate (ADC) linker and click-chemistry reagent containing an azide group. It is used for bioconjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC), and is suitable for ADC synthesis and related chemical biology applications. Purity is 99.53%, molecular weight 240.22 g/mol, formula C9H12N4O4. Storage: pure form -20°C for long-term stability.

  • Noncleavable ADC linker for antibody-drug conjugate synthesis.
  • Enables copper-catalyzed azide-alkyne cycloaddition (CuAAC).
  • Compatible with strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN.
  • High purity: 99.5% to support sensitive conjugation reactions.
  • Stored at -20°C in pure form for up to 3 years.

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