Crosslinking Reagents
Thermo Scientific™ Pierce™ Controlled Protein-Protein Crosslinking Kit
Chemically conjugate any two purified proteins (antibodies, enzymes, carriers, etc.) using sulfo-SMCC crosslinker, a complete kit with modification reagents and buffers.
Cell Signaling Technology Posibeads™ Whitlow/218 Linker Positive Control Beads, 50 Assays
Posibeads™ are 5 nm non-fluorescent polystyrene beads coated with Whitlow/218 linker peptide, designed as a specific positive control for antibody conjugates in flow cytometry. The beads behave like cells in suspension and are compatible with standard immunostaining and wash protocols. They facilitate reliable confirmation of specific binding and fluorescence, enabling comparison of intensity across instruments and experiments.
- Function as a specific positive control targeting Whitlow/218 linker antibody conjugates.
- Support use as standalone samples or internal controls mixed with cells.
- Enable comparison of fluorescence across multiple sites, timepoints, and instruments.
- Supplied in 1X PBS (pH 7.4) with 0.05% Tween 20 and 0.05% sodium azide.
- Storage requirement: 4°C.
Cell Signaling Technology Posibeads™ G4S Linker Positive Control Beads, 5 nm Polystyrene, 50 Assays
These 5 nm non-fluorescent polystyrene beads are coated with G4S linker peptide to serve as a specific positive control for confirming binding and fluorescence of G4S linker-targeted antibody conjugates in flow cytometry. The beads behave like cells in suspension and can be processed alongside cell samples using standard immunostaining and wash protocols. They may be used as a standalone sample or as an internal positive control to verify antibody activity and allow for consistent fluorescence comparisons across experiments and instruments.
- Specific control for G4S linker-targeted antibodies
- Functions as a standalone sample or internal positive control
- Compatible with standard cell-based immunostaining and wash protocols
- Enables consistent data comparison across instruments and experiments
- Supplied in 1X PBS (pH 7.4), 0.05% Tween 20, and 0.05% sodium azide
Kyfora Bio TriEGDA 25g
TriEGDA is a crosslinking monomer Crosslinking polymeric materials can be used to synthesize hydrogels which are suitable carriers for controlled drug delivery
Med Vet International 16mg Apoquel Tablets, 100ct
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Apoquel is used to treat and control itching and inflammation in dogs resulting from a variety of causes, including flea allergy, food allergy, contact allergy and atopic dermatitis. Apoquel delivers onset of relief within 4 hours. It effectively controls itching within 24 hours.
Perkin Elmer US LLC SPB Probe 6 in. for 50 mL Tubes
The SPB Probe provides direct control and monitoring of actual sample temperature via a corrosion-resistant, PFA-coated temperature probe. Each probe is supplied with five Probe Watch Glasses and a probe holder.
Medchemexpress LLC PEG4-SPDP | 1305053-43-3 | 98.0% | 488.57 | C20H28N2O8S2 | 50 MG
PEG4-SPDP is a cleavable polyethylene glycol (PEG)-spaced SPDP crosslinker used as an antibody-drug conjugate (ADC) linker for research applications. It contains an NHS-ester and a pyridyldithiol reactive group enabling amine-to-sulfhydryl conjugation and reductive cleavage for controlled payload release.
- Cleavable linker enabling controlled release under reducing conditions.
- NHS-ester and pyridyldithiol functional groups for amine-to-sulfhydryl conjugation.
- PEG4 spacer provides increased solubility and reduced steric hindrance.
- High purity suitable for research use.
- Supplied as a solid in small pack sizes for laboratory conjugation workflows.
Medchemexpress LLC Peg4-spdp | 1305053-43-3 | 488.57 g/mol | C20H28N2O8S2 | 250 MG
PEG4-SPDP is a cleavable polyethylene glycol (PEG4) spacer variant of the SPDP crosslinker used as an ADC linker and general bioconjugation reagent. It features an N-hydroxysuccinimide (NHS) ester for amine coupling and a 2-pyridyldithiol group for thiol coupling, providing a reducible disulfide linkage for controlled payload release in reducing environments.
- Cleavable disulfide linker for controlled payload release in reducing environments.
- Amine-reactive NHS ester for conjugation to lysine residues.
- 2-pyridyldithiol group for thiol coupling and disulfide bond formation.
- Suitable for antibody-drug conjugates and protein crosslinking.
- Stable as a solid at -20°C; store solutions at lower temperatures for short-term use.
Cayman Chemical 12-keto Lithocholic Acid, Purity: ≥98%, CAS: 5130-29-0, 50 mg
A metabolite of DCA; fecal levels are elevated in rats fed a diet supplemented with cholic acid or DCA compared with rats fed a control diet or a diet supplemented with cholesterol, HDCA, or LCA; activates the human PXR (EC50 = 31.3 μM in a cell-based transactivation assay); levels are increased in duodenal bile from patients with type 2 diabetes
Medchemexpress LLC PC SPDP-NHS carbonate ester | 2279944-61-3 | MFCD31811480 | 95.0% | 608.64 | C25H28N4O10S2 | 5 MG
PC SPDP-NHS carbonate ester is a photocleavable carbonate NHS ester linker used for bioconjugation and the construction of antibody-drug conjugates (ADCs). It provides an NHS carbonate reactive site for coupling to primary amines and a photolabile unit that enables controlled payload release.
- Cleavable photocleavable linker suitable for ADC synthesis
- Contains an NHS carbonate reactive group for amine conjugation
- Purity 95.0%
- Molecular weight 608.64
- Soluble in common organic solvents such as DMSO
- Supplied in small research pack sizes for laboratory use
Medchemexpress LLC Sulfo-LC-SPDP sodium | 169751-10-4 | 527.57 | C18H22N3NaO8S3 | 10 MG
Sulfo-LC-SPDP sodium is a thiol-cleavable, heterobifunctional linker used to conjugate payloads to antibodies via a disulfide bond. It provides a water-soluble long-chain spacer and a pyridinyldithiol reactive group to enable payload release under reducing conditions. Intended for research use only.
- cleavable disulfide linker for controlled payload release
- heterobifunctional reactivity for amine and thiol conjugation
- water-soluble sodium salt for improved aqueous handling
- long-chain spacer reduces steric hindrance at the conjugation site
- suitable for antibody-drug conjugate synthesis and bioconjugation workflows
- molecular weight 527.57 and formula C18H22N3NaO8S3
Medchemexpress LLC DSG-PEG (MW 2000) | 308805-39-2 | 100.0% | 2000 Da (average) | C130H258O50 (average) | 50 MG
DSG-PEG (average MW 2000 Da) is a PEGylated lipid supplied as a high-purity solid for use in liposome and lipid nanoparticle formulation. It provides a methoxy-PEG chain anchored to a distearoyl glycerol lipid to incorporate into bilayers and modify surface properties.
- Provides steric stabilization to liposomes and lipid nanoparticles.
- Incorporates into lipid bilayers via a distearoyl glycerol anchor.
- Average PEG molecular weight ~2000 Da for controlled hydration layer.
- High purity solid suitable for research-scale formulation.
- Compatible with common solvents used in lipid film hydration and nanoparticle assembly.
- Powder storage at -20°C preserves stability for long-term storage.
Medchemexpress LLC Sulfo-SANPAH | 102568-43-4 | MFCD00054986 | 99.8% | 470.41 g/mol | C16H18N6O9S | 5 MG
Sulfo-SANPAH is a heterobifunctional, photo-reactive cross-linker that couples primary amines to surfaces using an N-hydroxysuccinimide (NHS) ester and a UV-activated nitrophenyl azide. It is water-soluble and widely used to immobilize extracellular matrix proteins onto hydrogels and other substrates for cell culture and biomaterials applications.
- Heterobifunctional reagent enabling covalent coupling via an NHS ester and a photoactivated azide.
- Water-soluble sulfonate improves solubility for aqueous surface modification.
- Photoactivation allows spatially controlled immobilization using UV light.
- High purity supports reproducible surface functionalization.
- Suitable for immobilizing extracellular matrix proteins onto hydrogels and biomaterials.
Medchemexpress LLC 3,3'-dithiobispropionic acid bis-sulfosuccinimidyl ester disodium salt | 81069-02-5 | MFCD00054980 | 98.9% | 564.54 g/mol | C14H16N2O14S4 | 5 MG
DTSSP (3,3'-dithiobis(sulfosuccinimidyl propionate)) is a cleavable disulfide-containing crosslinker used in biochemical research as a reversible protein crosslinker and as a linker in antibody-drug conjugate (ADC) synthesis. It couples to primary amines via NHS-ester chemistry to form stable amide bonds and is designed to be cleaved under reducing conditions to release linked moieties.
- Cleavable disulfide-containing crosslinker enabling reversible linkage.
- Reacts with primary amines via NHS-ester chemistry to form stable amide bonds.
- Cleavable under reducing conditions for controlled release of conjugates.
- Suitable for antibody-drug conjugate linker synthesis and protein crosslinking.
- Available in small laboratory pack sizes for research use.
Med Vet International Apoquel Chewable Tablets (Oclacitinib Chewable Tablet), 16mg, 250 Count
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Apoquel Chewable (oclacitinib chewable tablet) is an oral chewable tablet that works differently from other skin allergy medications for dogs. It goes straight to the source to help relieve itch and inflammation at its core. Provides rapid relief from allergic dermatitis and has demonstrated to control allergic pruritus within 24 hours. Addresses the underlying cause of irritation and soothes allergic reactions For dogs older than 12 months of age to help lessen itch and inflammation due to allergic dermatitis Ideal for both short- or long-term treatment and can help to offer relief without many of the side effects associated with other medications
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