Bioactive Small Molecules
Selleck Chemical LLC Selleck Chemicals Zosuquidar 3HCl, P-gp Modulator, 60 nM Ki, CAS 167465-36-3
Zosuquidar 3HCl is a potent modulator of P-glycoprotein-mediated multi-drug resistance, in Phase 3 development. It inhibits P-glycoprotein-mediated efflux, restoring drug sensitivity.
- Potent modulator of P-glycoprotein-mediated multi-drug resistance.
- Ki of 60 nM in a cell-free assay.
- Inhibits equilibrium binding of Pgp.
- Cytotoxic to drug-sensitive and MDR cell lines (IC50 6 μM to 16 μM).
- Restores drug sensitivity in P-gp-expressing leukemia cell lines.
- Enhances cytotoxicity of anthracyclines and ozogamicin in AML blasts.
- Inhibits (Z)-endoxifen transport in ABCB1-transduced cells.
- Molecular weight: 636.99.
- Formula: C32H31F2N3O2.3HCl.
- CAS number: 167465-36-3.
![eMolecules 1702809-17-3 | THZ531 | Selleck Chemicals | 558.08 | C30H32ClN7O2 | CN(C)CC=CC(=O)Nc1ccc(cc1)C(=O)N1CCCC(C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 | 5mg | 696799979](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC2456228.JPG-250.jpg)
eMolecules 1702809-17-3 | THZ531 | Selleck Chemicals | 558.08 | C30H32ClN7O2 | CN(C)CC=CC(=O)Nc1ccc(cc1)C(=O)N1CCCC(C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 | 5mg | 696799979
Pharmablock | 57-dichloro-3H-imidazo[45-b]pyridine | 25mg | 624170475 | PBT0271 | 24485-01-6 | MFCD13189664 | 188.010 | C6H3Cl2N3
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Apexbio Technology LLC Uridine, 50mg. Cas: 58-96-8 MFCD: MFCD00006526. DNA/RNA synthesis chemical
Uridine, Trisodium Salt is an energy-rich precursor in the enzymatic biosynthesis of RNA, a potent vasodilator, and induces contractile responses in some tissues. Other sizes are available. Please inqury us for quote.
Selleck Chemical LLC Dibutyryl-cAMP sodium salt, 2 g, powder, 99.96% purity, off-white
Dibutyryl-cAMP sodium salt, 2 g, powder, 99.96% purity, off-white
Selleck Chemical LLC PF-06821497, 5 MG, Mevrometostat, inhibitor of EZH2, -20°C storage, research use only
PF-06821497, 5 MG, Mevrometostat, inhibitor of EZH2, -20°C storage, research use only
Selleck Chemical LLC Navitoclax (ABT-263) 10mM/1mL 923564-51-6
Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ? 0.5 nM, ?1 nM and ?1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Tirzepatide, 5 mg, synthetic dual agonist for GIP and GLP-1 receptors, powder
Tirzepatide (LY3298176) sodium is a high-purity, synthetic dual agonist for GIP and GLP-1 receptors, recognized for its effectiveness in promoting glucose-dependent insulin secretion and enhancing glucose tolerance. This compound is noted for its potential to aid in weight reduction and improving metabolic parameters.
- High purity: 99.96%
- 99% plasma protein binding to albumin
- Molecular weight: 4813 g/mol
- CAS number: 2023788-19-2
- Storage stability: 3 years at -20°C (powder), 1 year at -80°C (aliquoted stock solutions)
- Solubility in DMSO: 100 mg/mL (20.77 mM)
- Peptide length: 39 amino acids
- Chemical modification for improved stability and uptake
Selleck Chemical LLC 34-Dichlorophenyl isocyanate E2896-5MG
3 4-Dichlorophenyl isocyanate(1 2-Dichloro-4-isothiocyanatobenzene) is a chemical compound used as a chemical intermediate and in organic synthesis
Selleck Chemical LLC 5-Methyl furfural S9381-25MG
5-Methyl furfural is an important chemical intermediate
Selleck Chemical LLC 4-Methyl-8-nitroumbelliferone S9331-25MG
7-Hydroxy-4-methyl-8-nitrocoumarin is a chemical