Bioactive Small Molecules
Invitrogen™ Ionomycin, Calcium Salt
Ionomycin is an effective Ca2+ ionopohre that is commonly used to both modify intracellular Ca2+ concentrations and to calibrate fluorescent Ca2+ indicators when studying the regulatory properties of Ca2+ in cellular processes.
Invitrogen™ BODIPY™ 493/503 (4,4-Difluoro-1,3,5,7,8-Pentamethyl-4-Bora-3a,4a-Diaza-s-Indacene)
BODIPY™ 493/503 can be used as a stain for neutral lipds, and as a tracer for oil and other nonpolar lipids.
Invitrogen™ Bis-ANS (4,4'-Dianilino-1,1'-Binaphthyl-5,5'-Disulfonic Acid, Dipotassium Salt)
Binds with affinity that is often orders-of-magnitude higher than 1-8-ANS as probe for nonpolar cavities in proteins
Invitrogen™ Brefeldin A (from Penicillium brefeldianum)
The fungal metabolite brefeldin A (BFA) has multiple targets in cells and has proven valuable for dissecting the cellular processes, including vesicle formation and kinesin distribution, involved in exporting newly synthesized proteins.
Invitrogen™ Nigericin, Free Acid
For intracellular calibration of fluorescence response of cytosolic pH indicators
Invitrogen™ Muscimol, BODIPY™ TMR-X Conjugate
Muscimol is a powerful agonist of the GABAA receptor and has been widely used to reversibly inactivate localized groups of neurons.
Invitrogen™ Methotrexate, Fluorescein, triammonium Salt (Fluorescein Methotrexate)
To probe DHFR expression
Invitrogen™ ANTS (8-Aminonaphthalene-1,3,6-Trisulfonic Acid, Disodium Salt)
Polyanionic dye often used in combination with the cationic quencher DPX for membrane fusion or permeability assays, including complement-mediated immune lysis
Invitrogen™ Dexamethasone Fluorescein
The synthetic steroid hormone dexamethasone binds to the glucocorticoid receptor, producing a steroid-receptor complex that then localizes in the nucleus and regulates gene transcription.
Invitrogen™ Octadecyl Rhodamine B Chloride (R18)
Lipophilic octadecyl rhodamine B binds to membranes with fluorophore at aqueous interface and alkyl tail protruding into lipid interior