Bioactive Small Molecules
CYTION U-343 MG Cells, 1 cryovial, Organism- Human, Tissue- Brain, Disease- Glioblastoma
The U-343 MG cell line is derived from a human glioblastoma, a type of aggressive brain tumor. Originally isolated from a 54-year-old Caucasian male, this cell line has been widely used in neurological research, particularly in studies concerning the pathology and therapeutic treatment strategies for glioblastoma. The U-343 MG cell line is notable for its astrocytic properties, resembling those of astrocytes in the brain, which makes it particularly useful for studying tumor behavior and neurobiology in a controlled in vitro environment.Genetically, the U-343 MG cells are characterized by various mutations typical of glioblastoma, including alterations in the TP53 gene and the EGFR gene. These mutations not only offer insights into the molecular underpinnings of glioblastoma malignancy but also serve as potential targets for therapeutic intervention.
Revvity Health Sciences Inc HTRF Human Total CHK2 Detection Kit, Control Lysate
HTRF Human Total CHK2 Detection Kit, Control Lysate
Medchemexpress LLC Tissue Type Plasminogen Activator Antibody (YA3206) | 100 UL
Tissue Type Plasminogen Activator Antibody (YA3206) is a rabbit-derived, non-conjugated IgG monoclonal antibody that targets Tissue Type Plasminogen Activator (tPA). tPA is an enzyme that converts plasminogen into active plasmin by cleaving a specific Arg-Val bond. It plays key roles in tissue remodeling, degradation, cell migration, and various physiopathological processes, including contributing to polyspermy prevention during oocyte activation. This antibody is for research use only.
- Host: Rabbit
- Clonality: Monoclonal
- Species reactivity: Human, mouse, rat
- Purity: Affinity chromatography
- Molecular weight: 63 kDa
- Applications: WB, IHC-P
- Storage: Stored at -20°C for 1 year; avoid repeated freeze / thaw cycles
Medchemexpress LLC Tissue Type Plasminogen Activator Antibody (YA3206) | 50 UL
Tissue Type Plasminogen Activator Antibody (YA3206) is a rabbit-derived, non-conjugated IgG monoclonal antibody that targets Tissue Type Plasminogen Activator. It is intended for research use only and aids in the study of tissue remodeling, degradation, cell migration, and other physiopathological events.
- Host: Rabbit
- Clonality: Recombinant, monoclonal
- Conjugation: Non-conjugated
- Modification: Unmodified
- Isotype: IgG
- Species reactivity: Human, mouse, rat
- Immunogen: A synthesized peptide derived from human PLAT aa533-562/562
- Appearance: Liquid
- Formulation: Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide, and 0.05% BSA
- Applications: WB, IHC-P
- Sensitivity: Endogenous
Medchemexpress LLC Rabbit IgG Isotype Control | 50 UL
This non-conjugated, rabbit-originated polyclonal antibody serves as an isotype control, designed for research use only. Isotype controls are essential for estimating nonspecific binding from target primary antibodies, ensuring accurate results by matching the immunoglobulin type and concentration of the target antibody.
- Host: Rabbit
- Clonality: Polyclonal
- Species reactivity: Species independent
- Immunogen: Synthetic peptide corresponding to rabbit IgG
- Conjugation: Non-conjugated
- Isotype: IgG
- Appearance: Liquid
- Formulation: PBS, 50% glycerol, 0.5% BSA, 0.02% sodium azide (pH 7.3)
- Storage & stability: 1 year at -20°C, avoid freeze/thaw cycles
- Research field: Epigenetics and nuclear signaling
- RRID: AB_3102988
- Applications: WB, IHC (P/F), IF (Tissue/ICC), FC, ELISA (assay-dependent)
Medchemexpress LLC Recombinant mouse tissue factor pathway inhibitor 2 (TFPI2), C-terminal hFc tag | >95.0% | 100 UG
Recombinant mouse tissue factor pathway inhibitor 2 (TFPI2) expressed in HEK293 cells with a C-terminal human Fc (hFc) tag. Supplied as a purified recombinant protein in a 100 μg format with >95.0% purity, intended for biochemical assays, protein-protein interaction studies, and immunodetection applications.
- Expressed in HEK293 cells for mammalian-like post-translational modifications.
- C-terminal hFc tag enables easy detection and affinity capture.
- High purity (>95.0%) as determined by Tris-Bis PAGE.
- Provided in a 100 μg format for assay development and controls.
- Suitable for biochemical assays, binding studies, and immunoassays.
Medchemexpress LLC Gcn2-in-7, general control nonderepressible 2 (GCN2) inhibitor | 2396465-33-9 | C22H23BrN8OS | 25 MG
GCN2-IN-7 (compound 39) is an orally active and selective general control nonderepressible 2 (GCN2) inhibitor with an IC50 of 5 nM. It shows anti-tumor activity in vivo. The compound appears as a solid, white to off-white, with a molecular weight of 527.44.
- IC50: 5 nM (GCN2).
- Alleviates myeloid-derived suppressive cells (MDSC)-related T cell suppression and restores T cell proliferation at 600 nM for 3 days in vitro.
- Shows robust target engagement in vivo at 15 mg/kg (oral gavage; BID; 17 days) in Balb/c mice injected with RENCA cells, with an average of 84% in tumor and 80% in spleen tissues, and a 65% reduction of ATF4.
- Inhibits tumor growth by 56% after 26 days of dosing in an LL2 syngeneic mouse model at 50 mg/kg (oral gavage; BID; 17 days).
TOPOGEN INC Human Topoisomerase I
High purity, catalytically active Human Topoisomerase I overexpressed in the baculovirus system and purified to single band homogeneity. These preparations are cheaper than native top1 made from human tissue and offer excellent purity and high specific activity. In addition, the 100 kDa form of recombinant topo I is stable and is less prone to proteolysis, relative to the native protein from human cells. The final preparation of Topo 1 is highly active in relaxation of plasmid DNA. Topo I as prepared and purified using the baculovirus overexpression system. Activity was determined by serial 2 fold dilutions using supercoiled DNA. One unit of Human Topo I can relax >50% of 0.25 μg (250 ng) of supercoiled plasmid DNA in 30 minutes at 37°C.
American Research Products Inc Human cystathionine b synthase
Human cystathionine b-synthase (CBS) ELISA Kit from CUSABIO Detection Range 125 pg/mL-8000 pg/mL Sensitivity 31 25 pg/mL Sample serum plasma tissue homogenates cell lysates Method Sandwich
Medchemexpress LLC IgG1 Protein Human 5ug
Recombinant human IgG1 Fc variant containing D239E and L241E substitutions, produced in HEK293 cells and supplied as a 5 μg vial for research use. Intended as an assay control and for antibody engineering, receptor-binding, or functional assays that require a defined human IgG1 Fc variant.
- Recombinant human IgG1 with D239E and L241E mutations.
- Produced in HEK293 expression system for human-like glycosylation.
- Supplied as 5 μg for small-scale assays and controls.
- Approximate molecular weight 32-34 kDa (glycosylated).
- High reported purity (98%).
- Suitable for antibody engineering and receptor-binding or functional assays.
Medchemexpress LLC Epiregulin Human H 2ug
Epiregulin Protein a ligand for EGFR and ERBB4 crucially influences inflammation wound healing tissue repair and oocyte maturation It stimulates tyrosine phosphorylation of both receptors regulating angiogenesis vascular remodeling and cell proliferation Interactions with EGFR and ERBB4 contribute to intricate signaling pathways essential for diverse physiological responses and cellular functions Epiregulin Protein Human (HEK293 Fc) is the recombinant human-derived Epiregulin protein expressed by HEK293 with N-hFc labeled tag
Medchemexpress LLC CD39L1/ENTPD2 Human 10ug
CD39L1/ENTPD2 protein expressed in the nervous system efficiently hydrolyzes ATP and various nucleotides while showing limited hydrolysis of ADP Its substrate specificity hierarchy highlights its regulatory role in purinergic signaling and selective nucleotide hydrolysis contributing to precise control of neurotransmission CD39L1/ENTPD2 Protein Human (HEK293 His) is the recombinant human-derived CD39L1/ENTPD2 protein expressed by HEK293 with C-6 His labeled tag
Medchemexpress LLC CD39L1/ENTPD2 Human 50ug
CD39L1/ENTPD2 protein expressed in the nervous system efficiently hydrolyzes ATP and various nucleotides while showing limited hydrolysis of ADP Its substrate specificity hierarchy highlights its regulatory role in purinergic signaling and selective nucleotide hydrolysis contributing to precise control of neurotransmission CD39L1/ENTPD2 Protein Human (HEK293 His) is the recombinant human-derived CD39L1/ENTPD2 protein expressed by HEK293 with C-6 His labeled tag
Medchemexpress LLC APOBEC3A Human His 5ug
Recombinant human APOBEC3A protein expressed in Escherichia coli, supplied with N-terminal 6xHis and SUMO tags. APOBEC3A is a DNA cytosine deaminase commonly used to study viral restriction, DNA editing, and enzymatic activity in biochemical and molecular biology assays. Available in microgram-scale quantities for laboratory research.
- Recombinant human protein expressed in Escherichia coli.
- N-terminal 6xHis and SUMO tags for purification and stability.
- Suitable for enzymatic assays, DNA deamination studies, and biochemical characterization.
- Available in multiple microgram-scale pack sizes for small-scale experiments.
- Quality-controlled for research applications.
Medchemexpress LLC Epiregulin Human H 10ug
Epiregulin Protein a ligand for EGFR and ERBB4 crucially influences inflammation wound healing tissue repair and oocyte maturation It stimulates tyrosine phosphorylation of both receptors regulating angiogenesis vascular remodeling and cell proliferation Interactions with EGFR and ERBB4 contribute to intricate signaling pathways essential for diverse physiological responses and cellular functions Epiregulin Protein Human (HEK293 Fc) is the recombinant human-derived Epiregulin protein expressed by HEK293 with N-hFc labeled tag