Custom Peptides
Cayman Chemical N-desmethyl Azelastine, Purity: ≥98%, CAS: 47491-38-3, 10 mg
An active metabolite of azelastine; inhibits acetylcholine-induced depolarization and contractions in isolated human tracheal smooth muscle at 1 µM; inhibits transport of daunorubicin and digoxin in LLC-GA5-CoL150 cells overexpressing P-gp (IC50s = 11.8 and 41.8 µM, respectively)
Cayman Chemical ML-00253764 (hydrochloride), Purity: ≥98%, CAS: 1706524-94-8, 10 mg
A MC4R antagonist (Ki = 0.16 µM); selective for MC4R over MC3R and MC5R (IC50s = 0.32, 0.81, and 2.12 µM, respectively); decreases cAMP production induced by [NDP]-α-MSH by 20% in MCR4-expressing HEK293 cell membranes, but has no effect on cAMP levels in MC3R- or MC5R-expressing HEK293 cell membranes at 100 µM; prevents the loss of lean body mass and enhances light-phase food consumption in a LLC mouse xenograft model but does not reduce tumor size at 15 mg/kg
Cayman Chemical 1-Deoxysphinganine (m18:0), Purity: ≥95%, CAS: 196497-48-0, 10 mg
An atypical sphingolipid; plasma levels of 1-deoxysphinganine are increased in patients with HSAN1 and GSDI; not converted to canonical sphingolipids or fatty acids and accumulates in mitochondria, inducing mitochondrial fragmentation and dysfunction; accumulates in LLC-PK1 cells and in mouse liver and kidney following application or administration, respectively, of fumonison B1; neurotoxic to dorsal root ganglion neurons in vitro at 1 µM; cytotoxic to DU145 cells (IC50 = ~2 µM) but stimulates DNA synthesis in Swiss 3T3 cells at 1 µM