Bovine Secondary Antibodies
Cayman Chemical ANTIBODY Mometason 500ug
A synthetic glucocorticoid; reduces pulmonary edema and neutrophil infiltration in a mouse model of chlorine-induced chemical lung injury at 3 mg/kg; intranasal administration reduces nose-rubbing behavior, sneezing, and nasal mucosal levels of IL-4 in a mouse model of allergic rhinitis at 0.2 UG/animal; reduces nasal mucosal epithelial destruction, fibrosis, and cilia loss in a rat model of oxymetazoline-induced rhinitis medicamentosa
Cayman Chemical Ginsenoside CK, Purity: ≥95%, CAS: 39262-14-1, 5 mg
A metabolite of ginsenoside Rb1; formed from ginsenoside Rb1 via intestinal bacterial exo-β-D-glucosidase; reduces protein levels of MMP-2 and pro-MMP-9, and inhibits growth, adhesion, and invasion of, MHCC97-H HCCs at 50 and 75 µM; inhibits metastasis in an MHCC97-H mouse xenograft model; reduces the percentage of memory B cells in the spleen, the number of swollen joints, and lymph node hyperplasia in an adjuvant-induced model of rheumatoid arthritis; reduces the accumulation of Aβ42 in the rat hippocampal CA1 and CA3 regions in a rat model of vascular dementia; also increases the percentage of time spent in the target quadrant of the Morris water maze at 100 and 200 mg/kg in a rat model of vascular dementia
Cayman Chemical Ginsenoside CK, Purity: ≥95%, CAS: 39262-14-1, 10 mg
A metabolite of ginsenoside Rb1; formed from ginsenoside Rb1 via intestinal bacterial exo-β-D-glucosidase; reduces protein levels of MMP-2 and pro-MMP-9, and inhibits growth, adhesion, and invasion of, MHCC97-H HCCs at 50 and 75 µM; inhibits metastasis in an MHCC97-H mouse xenograft model; reduces the percentage of memory B cells in the spleen, the number of swollen joints, and lymph node hyperplasia in an adjuvant-induced model of rheumatoid arthritis; reduces the accumulation of Aβ42 in the rat hippocampal CA1 and CA3 regions in a rat model of vascular dementia; also increases the percentage of time spent in the target quadrant of the Morris water maze at 100 and 200 mg/kg in a rat model of vascular dementia
Cayman Chemical ANTIBODY OPPD-Q 500ug
A PPD-Q and an oxidized derivative of OPPD; not toxic to rainbow trout (O. mykiss) at concentrations up to 50 UG/L for 96 hours
Cayman Chemical ANTIBODY HyperIcIn 500ug
An anthroquinone derivative found in St. John’s wort; inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA, and L-glutamate; broad spectrum phototoxic effects (IC50 = 140-1570 nM) in cancer cells; induces apoptotic signaling and formation of ROS; in vitro antiviral activity against HIV, influenza, hepatitis C, murine cytolomegalovirus, and herpes viruses
Cayman Chemical ANTIBODY LSN3318839 500ug
A positive allosteric modulator of GLP-1R; potentiates increases in cAMP accumulation induced by GLP-1 (9-36) in INS-1 832/3 cells; increases insulin levels in the presence, but not absence, of GLP-1 (9-36) in INS-1 832/3 cells under high-glucose conditions at 1 and 3 µM; reduces blood glucose levels in GIPR knockout mice in an oral glucose tolerance test at 30 mg/kg; has an additive effect on reducing blood glucose levels in GIPR knockout mice at 10 or 30 mg/kg in combination with sitagliptin
Cayman Chemical TopIramate-d12 500ug
An internal standard for the quantification of topiramate by GC- or LC-MS
Cayman Chemical ANTIBODY H3B-8800 500ug
An inhibitor of the SF3B complex; binds to SF3B complexes containing wild-type SF3B (IC50 = 1.4 nM) or various SF3B mutations (IC50s = 0.3-1.8 nM); inhibits SF3B1-induced splicing of canonical and aberrant pre-mRNA junctions in HEK293T nuclear extracts overexpressing SF3B1K700E; selectively inhibits the growth of, and induces apoptosis in, Panc 05.04 pancreatic cancer cells expressing mutant SF3B over Panc 10.05, HAPF-II, and CFPAC-1 pancreatic cancer cells expressing wild-type SF3B in a concentration-dependent manner; reduces tumor growth in a K562 mouse xenograft model using K562 cells expressing wild-type SF3B1 at 8 mg/kg and K562 cells expressing SF3B1K700E at 2, 4, or 8 mg/kg
Cayman Chemical ANTIBODY VIpadent 500ug
A selectve adenosine A2A receptor antagonist (Kis = 1.3, 68, 63, and 1,005 nM for A2A, A1, A2B, and A3 receptors, respectively in a radio ligand binding assay); acts as a functional antagonist of human recombinant A2A (KA = 0.58 nM) in a calcium mobilization-based FLIPR assay; reverses haloperidol-induced hypolocomotion in mice and rats
Cayman Chemical ANTIBODY TAS 120 500ug
An orally bioavailable inhibitor of FGFRs that irreversibly inhibits all four FGFR subtypes at nanomolar concentrations; blocks the proliferation of human cancer cell lines with FGFR gene abnormalities
Cayman Chemical ANTIBODY Eltenac 500ug
A non-selective COX inhibitor (IC50 = 0.03 µM for both COX-1 and COX-2 in isolated human whole blood); reduces lameness in horses with tendinitis, pododermatitis, navicular disease, non-infectious arthritis, degenerative joint disease, phalanx fracture, and osteochondrosis at 1 mg/kg; reduces castration-induced edema in hors
Cayman Chemical ANTIBODY BX-320 500ug
An inhibitor of PDK1 (IC50 = 30 nM); selective for PDK1 over a panel of 10 additional kinases (IC50s = >820 nM for all); inhibits Akt and p70S6K1 phosphorylation in PC3 cells (IC50s = 1-3 µM); induces apoptosis in, and inhibits the growth of, MDA-MB-468 breast cancer cells (IC50s = 0.5 and 0.6 µM, respectively), as well as inhibits cell growth in a panel of cancer cells (IC50s = 0.12-1.2 µM); inhibits the growth of lung tumors in a LOX melanoma mouse model of blood-borne metastasis at 200 mg/kg
Cayman Chemical Angiotensin Fragment 1-7 (acetate), Purity: ≥95%, 10 mg
An angiotensin metabolite that functions as a type 1 angiotensin II receptor agonist whereupon it can control hydroelectrolyte balance and demonstrates vasodilatory and anti-inflammatory actions in opposition to various adverse effects of angiotensin II
Cayman Chemical ANTIBODY BAY-985 500ug
A dual inhibitor of TBK1 and IKKε (IC50 = 2 nM for both); selective for TBK1 and IKKε over FLT3, RSK4, DRAK1, and ULK1 (IC50s = 123, 276, 311, and 7,390 nM, respectively); inhibits phosphorylation of IRF3 in MDA-MB-231 cells expressing mouse IRF3 (IC50 = 74 nM); inhibits the proliferation of SK-MEL-2 cells in vitro (IC50 = 900 nM); reduces tumor weight in an SK-MEL-2 mouse xenograft model at 200 mg/kg
Cayman Chemical ANTIBODY MSD-M1PAM 500ug
A positive allosteric modulator of M1 mAChRs; enhances ACh-induced calcium production in a calcium mobilization assay from 0.1-10 µM; reverses scopolamine-induced deficits in freezing behavior in mice from 1-30 mg/kg; attenuates deficits in self-ordered spatial search in cynomolgus macaques and in the object retrieval detour task in rhesus macaques