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Protein interaction antibody pairs are sets of antibodies that are known to be capable of detecting specific protein - protein interactions; they can be used together in an immunoassay.
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An inhibitor of FGFR4 (IC50 = 1.3 nM); selective for FGFR4 over FGFR1 and a panel of 36 kinases (IC50s = >10 µM for all); inhibits proliferation of Hep3B and Huh7 hepatic cancer cells with IC50 values of 1.1 and 2.5 nM, respectively; reduces tumor growth by 62.7 and 70.8% in a Huh7 mouse xenograft model at 30 and 100 mg/kg per day, respectively
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Source: Recombinant human MR1 and β2-microglobulin expressed in E. coli • Amino acids: 22-292 (MR1), 21-119 (β2-microglobulin) • MW: 32 (MR1) and 12 (β2-microglobulin) kDa
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