Dicarboxylic acids and derivatives
Selleck Chemical LLC NLX-101 S3510-5mg
NLX-101 (F-15599) is a highly selective 5-HT1A receptor biased agonist that mediates antidepressant-like activity in rats via prefrontal cortex 5-HT 1A receptors
Selleck Chemical LLC MZ-101-E1913-25MG
MZ-101 (GYS1-IN-2) is a potent small molecule inhibitor of Glycogen synthase 1(GYS1) with an IC50 value of 0 041 M By depleting muscle glycogen MZ-101 treatment normalizes glycogen levels and corrects transcriptional and metabolic abnormalities in Pompe mice
Selleck Chemical LLC MZ-101-E1913-100MG
MZ-101 (GYS1-IN-2) is a potent small molecule inhibitor of Glycogen synthase 1(GYS1) with an IC50 value of 0 041 M By depleting muscle glycogen MZ-101 treatment normalizes glycogen levels and corrects transcriptional and metabolic abnormalities in Pompe mice
Selleck Chemical LLC PHI-101-E1437-25MG
PHI-101 is an orally active potent third-generation inhibitor of FLT3 that overcomes resistance to multiple drug-resistant mutations It has potential for research in relapsed or refractory acute myeloid leukemia (AML)
Selleck Chemical LLC GlyH-101
GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4 3 M
Selleck Chemical LLC (R)-(-)-Gossypol (AT-101) acetic acid S2812-10mM/1mL
(R)-(-)-Gossypol (AT-101) acetic acid the R-(-) enantiomer of Gossypol acetic acid binds with Bcl-2 Bcl-xL and Mcl-1 with Ki of 0 32 M 0 48 M and 0 18 M in cell-free assays does not inhibit BIR3 domain and BID AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy Phase 2
Selleck Chemical LLC (R)-(-)-Gossypol (AT-101) acetic acid S2812-50mg
(R)-(-)-Gossypol (AT-101) acetic acid the R-(-) enantiomer of Gossypol acetic acid binds with Bcl-2 Bcl-xL and Mcl-1 with Ki of 0 32 M 0 48 M and 0 18 M in cell-free assays does not inhibit BIR3 domain and BID AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy Phase 2
Selleck Chemical LLC CUDC-101 S1194-1g
CUDC-101 is a potent multi-targeted inhibitor against HDAC EGFR and HER2 with IC50 of 4 4 nM 2 4 nM and 15 7 nM and inhibits class I/II HDACs but not class III Sir-type HDACs Phase 1
Selleck Chemical LLC CUDC-101 S1194-10mM/1mL
CUDC-101 is a potent multi-targeted inhibitor against HDAC EGFR and HER2 with IC50 of 4 4 nM 2 4 nM and 15 7 nM and inhibits class I/II HDACs but not class III Sir-type HDACs Phase 1
Selleck Chemical LLC Sulforhodamine 101-E0366-5MG
Sulforhodamine 101 (SR101) is a fluorescent dye and is widely used for astrocyte identification
Selleck Chemical LLC MZ-101-E1913-5MG
MZ-101 (GYS1-IN-2) is a potent small molecule inhibitor of Glycogen synthase 1(GYS1) with an IC50 value of 0 041 M By depleting muscle glycogen MZ-101 treatment normalizes glycogen levels and corrects transcriptional and metabolic abnormalities in Pompe mice
Selleck Chemical LLC (R)-(-)-Gossypol (AT-101) acetic acid S2812-1g
(R)-(-)-Gossypol (AT-101) acetic acid the R-(-) enantiomer of Gossypol acetic acid binds with Bcl-2 Bcl-xL and Mcl-1 with Ki of 0 32 M 0 48 M and 0 18 M in cell-free assays does not inhibit BIR3 domain and BID AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy Phase 2
Selleck Chemical LLC PHI-101-E1437-100MG
PHI-101 is an orally active potent third-generation inhibitor of FLT3 that overcomes resistance to multiple drug-resistant mutations It has potential for research in relapsed or refractory acute myeloid leukemia (AML)
Selleck Chemical LLC GlyH-101
GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4 3 M
Selleck Chemical LLC GlyH-101
GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4 3 M
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