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MK-5108 is a highly selective Aurora A inhibitor with IC50 of 0 064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C while it inhibits TrkA with less than 100-fold selectivity MK-5108 (VX-689) induces autophagy Phase 1
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Tedizolid is an oxazolidinone-class antibiotic prodrug used for the treatment of acute bacterial skin and skin structure infections caused by susceptible isolates of several Gram-positive bacteria
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Golvatinib (E7050) is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM does not inhibit bFGF-stimulated HUVEC growth (up to 1000 nM) Phase 1/2
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Tenalisib is a potent and selective dual PI3K / inhibitor with IC50 values of 24 5 nM and 33 2 nM for PI3K and PI3K respectively Its selectivity over and isoforms are more than 300-fold and 100-fold respectively
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HSP990 (NVP-HSP990) is a novel potent and selective HSP90 inhibitor for HSP90 / with IC50 of 0 6 nM/0 8 nM NVP-HSP990 induces cell cycle arrest and apoptosis
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Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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ART558 is a potent, selective, low molecular weight, allosteric inhibitor of DNA Pol? with an IC50 of 7.9 nM.CAS No. 2603528-97-6 *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Astragalus polyphenols(2 3 5 4 -Tetrahydroxystilbene-2-O-beta-D-glucopyranoside) is a wonderful immune enhancing herb that has strong anti-viral activity and produces extra interferon in the body It contains rich polyphenol with various effects including antioxidant and antiinflammatory actions
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R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM It is less potent to CDK7 and GSK3 / while inactive to other kinases Phase 1
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Encorafenib is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM Phase 3
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