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Organic compounds that consist of a benzene ring substituted with amino and carboxyl groups. Includes compounds that are derived from aminobenzoic acids.
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Masitinib mesylate (AB-1010 mesylate) is a potent orally bioavailable and selective inhibitor of c-Kit with IC50 of 200 nM for human recombinant c-Kit also inhibits PDGFR / with IC50s of 540/800 nM Lyn with IC50 of 510 nM for LynB and to a lesser extent FGFR3 and FAK
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Dabigatran etexilate mesylate (Pradaxa BIBR 1048MS Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective direct thrombin inhibitor (DTI) Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4 5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM
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Brevilin A (6-O-Angeloylplenolina) a sesquiterpene lactone isolated from Centipeda minima is a selective inhibitor of STAT3 and attenuates the JAKs activity by blocking the JAKs tyrosine kinase domain JH1 Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation
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3-Aminobenzamide (3-ABA 3-Amino Benzamide 3-AB) is a potent inhibitor of Poly(ADP-ribose)polymerase (PARP) and inhibits cell apoptosis after SCI (Spinal Cord Injury) in caspase-independent way
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Nafamostat mesilate is a synthetic serine protease inhibitor used as an anticoagulant during hemodialysis Nafamostat mesylate blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19 Nafamostat Mesilate attenuates inflammation and apoptosis
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Dabigatran etexilate mesylate (Pradaxa BIBR 1048MS Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective direct thrombin inhibitor (DTI) Dabigatran selectively and reversibly inhibits human thrombin with Ki of 4 5 nM and thrombin-induced platelet aggregation with IC50 of 10 nM
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Schisantherin A (Gomisin C Schisanwilsonin H Arisanschinin K) is a dibenzocyclooctadiene that exhibits anti-tussive sedative anti-inflammatory anti-osteoporotic neuroprotective cognition enhancing and cardioprotective activities Schisantherin A inhibits p65-NF- B translocation into the nucleus by I B degradation
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Anti-Sialyl-Lewis A is a human monoclonal antibody against the carbohydrate antigen sialyl-Lewis A (carbohydrate antigen 19-9 CA19-9) with potential antineoplastic activity MW 145 5 kD
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