Aminobenzoic acids and derivatives
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Medchemexpress LLC 3-amino-9-ethylcarbazole | 132-32-1 | MFCD00004964 | 99.6% | 210.28 g·mol^-1 | C14H14N2 | 50 G
3-Amino-9-ethylcarbazole (9-ethyl-9H-carbazol-3-amine, CAS 132-32-1) is an organic chromogenic reagent used for peroxidase-based detection in biochemical assays and immunohistochemical staining. Supplied as a high-purity solid for laboratory use, it is suitable for histology, immunoblotting, and related research applications.
- High purity (99.61%).
- Chromogenic substrate for peroxidase-based detection.
- Suitable for immunohistochemistry and immunoblotting.
- Solid form convenient for long-term storage and handling.
- Available in multiple pack sizes for laboratory needs.
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Medchemexpress LLC Dabrafenib Mesylate | 1195768-06-9 | 99.9% | 615.67 | 100 MG
Dabrafenib Mesylate is a potent and selective Raf kinase inhibitor with IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively. It is intended for research use only.
- Inhibits more than 90% of cell growth in NRAS mutant clones when combined with GSK1120212.
- Reduces S6P phosphorylation in A375 cells.
- Suppresses polyp-mediated vascular barrier permeability, inflammatory biomarker upregulation, leukocyte adhesion/migration, and activation/production of NF-κB, TNF-α, and IL-6.
- Inhibits HMGB1 release and downregulates HMGB1-dependent inflammatory responses by enhancing cell adhesion molecule (CAMs) expressions in human endothelial cells.
- In vivo studies showed that dabrafenib-treated females had mostly immature reproductive tracts with no evidence of ovulation, but keratinized and histologically open vaginas.