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PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
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NS-1619 is a small-molecule opener of large-conductance Ca2+-activated K+ (BK) channels used in pharmacology and physiology research. It is supplied as a solid or as a DMSO solution and is commonly used to probe ion channel function and vascular smooth muscle relaxation.