Dithiolanes
Sigma Aldrich 5-Amino-2-phenethylisoindoline-1,3-dione
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 5-Aminoisophthalic Acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 5-Bromoisophthalic acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 4-(1H-1,2,4-Triazol-1-yl)butanoic acid hydrochloride
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
![Sigma Aldrich 3-(4-Chloro-3-methylphenoxy)-8-[(dipropylamino)methyl]-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one](https://assets.fishersci.com/TFS-Assets/CCG/Sigma-Aldrich/product-images/5f6b3e48-37fb-41f4-b6e8-5b63609bed62.jpg-250.jpg)
Sigma Aldrich 3-(4-Chloro-3-methylphenoxy)-8-[(dipropylamino)methyl]-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Isophthalic acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Medchemexpress LLC 1,2-Dithiolane-3-pentanoic acid, 2,5-dioxo-1-pyrrolidinyl ester | 40846-94-4 | 98.0% | C12H17NO4S2 | 1 G
α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system. They achieve this by connecting two ligands with a linker: one targeting an E3 ubiquitin ligase and the other binding to the protein of interest. This product is for research use only.
- Alkyl/ether-based linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC (S)-thioctic acid | 1077-27-6 | MFCD01863481 | >=97.0% | 206.33 g/mol | C8H14O2S2 | 1 ML
(S)-Thioctic acid (S-lipoic acid) is the S-enantiomer of lipoic acid, a thiol-containing antioxidant and enzymatic cofactor used in biochemical research. It participates in redox chemistry and mitochondrial enzyme function. The product is supplied as a ready-to-use 10 mM solution in DMSO and as solids for preparative or analytical work, suitable for enzymology and antioxidant studies.
- Chiral antioxidant and mitochondrial cofactor
- Available as 10 mM solution in DMSO for immediate use
- Also available as solid for bulk or formulation
- Useful for enzymology, redox, and antioxidant assays
- High purity (≥97%) suitable for HPLC applications
- Stable when stored under recommended conditions
Medchemexpress LLC Alpha-Lipoic acid-NHS | 40846-94-4 | 98.0% | C12H17NO4S2 | 100 MG
Alpha-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs are designed to contain two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is intended for research use only.
- Alkyl/ether based PROTAC linker
- Used in synthesis of PROTACs
- Solid appearance
- White to yellow color
- Molecular weight of 303.40
- Purity of 98.0%
Medchemexpress LLC MRT-2359 | 2803881-11-8 | C22H17F4N3O6 | 25 MG
MRT-2359 is a potent, orally active, and selective GSPT1 depressant (IC50: >30 nM and <300 nM) that specifically induces apoptosis dependent on protein translation. It exhibits significant anti-proliferative activity in various cancer cell lines, particularly MYC-driven cell lines like non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high N-Myc or L-Myc expression, making it suitable for cancer research.
- Potent, orally active, and selective GSPT1 depressant
- Specifically induces apoptosis dependent on protein translation
- Significant anti-proliferative activity in MYC-driven cancer cell lines
- Effective against non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)
- Inhibits the growth of drug-resistant NSCLC and SCLC cells
- Reduces N-Myc protein expression and tumor size
- Active against prostate cancer
Medchemexpress LLC Alpha-lipoic acid choline ester chloride | 1808266-58-1 | 99.7% | 327.93 | C13H26ClNO2S2 | 5 MG
Alpha-lipoic acid choline ester chloride is a choline ester derivative of alpha-lipoic acid provided for laboratory research. It can reduce protein disulfides and has been studied for improving lens elasticity and other presbyopia-related effects. The compound is supplied as a solid and as prepared DMSO solutions; store sealed at 4°C and handle per standard laboratory safety procedures.
- Choline ester derivative of alpha-lipoic acid
- Reduces protein disulfides
- Enhances lens elasticity in preclinical studies
- Available as solid and 10 mM DMSO solutions
- High purity (99.7%)
- Molecular formula C13H26ClNO2S2; molecular weight 327.93
Medchemexpress LLC Alpha-lipoic acid-NHS | 40846-94-4 | 98.0% | C12H17NO4S2 | 250 MG
Alpha-lipoic acid-NHS is an alkyl/ether-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs feature two ligands connected by a linker, one for an E3 ubiquitin ligase and another for a target protein, enabling the selective degradation of target proteins via the intracellular ubiquitin-proteasome system. This compound has a molecular weight of 303.40 and is a white to yellow solid, intended for research use only.
- Alkyl/ether-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Molecular weight of 303.40
- Appears as a white to yellow solid
- Shipping at room temperature (continental US)
- Storage at -20°C, sealed, away from moisture
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Solubility in ethanol: 2 mg/mL (6.59 mM) with ultrasonic and warming to 60°C
Apexbio Technology LLC MRT-2359-10MG
MRT-2359 (CAS No 2803881-11-8) is a research compound in the biomedical field originating from studies of cellular signal transduction pathways It functions primarily by modulating specific protein targets involved in disease progression utilizing mechanisms such as enzyme inhibition or receptor modulation Its activity is typically observed in the nanomolar to low micromolar range making it effective in in vitro experiments Common applications include studies in various cell models animal studies for disease modeling and high-throughput drug screening platforms Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC MRT-2359-5MG
MRT-2359 (CAS No 2803881-11-8) is a research compound in the biomedical field originating from studies of cellular signal transduction pathways It functions primarily by modulating specific protein targets involved in disease progression utilizing mechanisms such as enzyme inhibition or receptor modulation Its activity is typically observed in the nanomolar to low micromolar range making it effective in in vitro experiments Common applications include studies in various cell models animal studies for disease modeling and high-throughput drug screening platforms Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC MRT-2359-1MG
MRT-2359 (CAS No 2803881-11-8) is a research compound in the biomedical field originating from studies of cellular signal transduction pathways It functions primarily by modulating specific protein targets involved in disease progression utilizing mechanisms such as enzyme inhibition or receptor modulation Its activity is typically observed in the nanomolar to low micromolar range making it effective in in vitro experiments Common applications include studies in various cell models animal studies for disease modeling and high-throughput drug screening platforms Experimental concentrations typically depend on the specific research design
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