The Mouse Reactive Senescence Marker Antibody Sampler Kit provides an economical solution for detecting diverse biomarkers of cellular senescence in mouse samples. Senescence, defined by stable stress-induced proliferative arrest and the secretion of senescence-associated secretory phenotype (SASP) proteins, is linked to aging and various pathologies. This kit includes primary antibodies sufficient for two western blot experiments each, plus an HRP-linked secondary antibody.
- Includes antibodies for cell cycle arrest markers: p16 INK4A and p21 Waf1/Cip1.
- Targets senescence-associated DNA damage via Phospho-Histone H2A.X (Ser139).
- Detects SASP-related proteins including HMGB1, IL-6, TNF-α, and MMP2.
- Contains an antibody to lamin B1, which is frequently reduced in senescent cells.
- Supplied with Anti-rabbit IgG, HRP-linked secondary antibody.