Benzothiazines
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Medchemexpress LLC BTZO-1 | 99420-15-2 | 99.3% | 240.28 | 100 MG
BTZO-1 is a chemical probe designed to bind to Macrophage migration inhibitory factor (MIF), with a Kd value of 68.6 nM, specifically requiring the N-terminal Pro1 for its binding. This compound demonstrates the ability to activate antioxidant response element (ARE)-mediated gene expression and effectively suppress oxidative stress-induced cardiomyocyte apoptosis in vitro.
- Suppresses serum deprivation-induced cardiomyocyte death at concentrations as low as 16 nM.
- Upregulates mRNA protein levels of GST Ya and HO-1 in cardiomyocytes.
- Suitable for research into neurological, eye or ear, inflammation, blood, cardio-cerebrovascular, digestive system, and neurodegenerative diseases.
- Available in solid form and solutions in DMSO.
- Stable for 3 years at -20°C as powder.
