Azetidines
Selleck Chemical LLC Azetidine-2-carboxylic acid
Azetidine-2-carboxylic acid (L-Aze) is a toxic and teratogenic non-protein amino acid that is misincorporated into protein in place of proline altering collagen keratin hemoglobin and protein folding
Selleck Chemical LLC Azetidine-2-carboxylic acid
Azetidine-2-carboxylic acid (L-Aze) is a toxic and teratogenic non-protein amino acid that is misincorporated into protein in place of proline altering collagen keratin hemoglobin and protein folding
Medchemexpress LLC 1-Boc-D-azetidine-2-carboxylic acid | 228857-58-7 | MFCD01320888 | >=97.0% | 201.22 g·mol⁻¹ | C9H15NO4 | 250 MG
1-Boc-D-azetidine-2-carboxylic acid is a Boc-protected D-azetidine amino acid derivative used as a chemical intermediate in medicinal chemistry and organic synthesis. It serves as a protected building block for introducing an azetidine unit into peptides and small molecules; intended for research use only.
- Boc-protected azetidine scaffold for synthetic incorporation.
- Suitable for peptide and small-molecule synthesis.
- Available in multiple pack sizes for scale flexibility.
- Typical purity ≥97% as supplied.
- Molecular formula C9H15NO4; molecular weight 201.22 g·mol⁻¹.
Medchemexpress LLC (R)-azetidine-2-carboxylic acid | 7729-30-8 | MFCD00800731 | 99.9% | 101.10 g/mol | C4H7NO2 | 5 G
(R)-azetidine-2-carboxylic acid is the R-enantiomer of azetidine-2-carboxylic acid supplied as a white to off-white solid for research and chemical synthesis. It is used as a non-cleavable ADC linker and as an alkyl chain building block for PROTACs and other conjugation chemistries. Store at 4°C and protect from light.
- High purity chiral building block for ADC and PROTAC linker synthesis.
- Molecular formula C4H7NO2; molecular weight 101.10 g/mol.
- Available in small-scale quantities, typically 5 g packaging.
- White to off-white solid; store at 4°C and protect from light.
Medchemexpress LLC Methyl azetidine-3-carboxylate hydrochloride | 100202-39-9 | MFCD01861758 | 99.7% | 151.59 | C5H10ClNO2 | 1 G
Methyl azetidine-3-carboxylate hydrochloride is a methyl-substituted azetidine carboxylate hydrochloride salt supplied as a white to off-white solid for research use. It is used as a non-cleavable ADC linker and as an alkyl chain-based PROTAC linker in medicinal chemistry and conjugation applications.
- High purity (99.7%) suitable for synthesis and conjugation.
- Solid form, white to off-white, easy to handle and weigh.
- Storage: sealed at 4°C; in solvent, -80°C up to 6 months or -20°C up to 1 month.
- Supplied in small research pack sizes (example: 1 G).
- Chemical identifiers: CAS 100202-39-9; formula C5H10ClNO2; molecular weight 151.59.
Medchemexpress LLC L-azetidine-2-carboxylic acid | 2133-34-8 | 99.9% | 101.10 g/mol | C4H7NO2 | 1 ML
L-azetidine-2-carboxylic acid is a proline analog research reagent used to study protein folding, endoplasmic reticulum (ER) stress, autophagy, and apoptosis pathways. It is supplied as a solid and as a 10 mM solution in water and has reported high chemical purity.
- Proline analog that perturbs protein synthesis and folding
- Induces ER stress and protein misfolding
- Upregulates LC3-II via PERK activation (autophagy marker)
- Increases pro-apoptotic BAX and induces ATF6 cleavage
- Available as solid and as a 10 mM, 1 mL aqueous solution
- High purity, reported at 99.85%
- CAS number 2133-34-8; formula C4H7NO2; molecular weight 101.10 g/mol
Medchemexpress LLC Clavulanate lithium | 61177-44-4 | 99.9% | 205.09 | C8H8LiNO5 | 10 MG
Clavulanate lithium is a β-lactamase inhibitor supplied as a high-purity analytical standard for laboratory research. It exhibits weak antibacterial activity alone but prevents inactivation of β-lactam antibiotics by microbial β-lactamases; intended for analytical and mechanistic studies. Not for clinical or human use.
- High purity (99.9%) appropriate for analytical applications.
- Chemical formula C8H8LiNO5; molecular weight 205.09 g/mol.
- Available in small, defined pack sizes for precise dosing and assays.
- Provided with manufacturer documentation and batch-specific certificates of analysis.
- Intended for research use only; not for therapeutic use.
Medchemexpress LLC Clavulanate potassium | 61177-45-5 | MFCD01710901 | 99.5% | 237.25 | C8H8KNO5 | 10 MG
Clavulanate potassium is the potassium salt of clavulanic acid, a potent β-lactamase inhibitor used in research to study antibiotic resistance and to enhance the activity of β-lactam antibiotics. It is supplied as a high-purity solid for in vitro assays, analytical testing, and formulation research.
- Potent β-lactamase inhibitor for resistance studies.
- Used to potentiate β-lactam antibiotics in combination assays.
- High purity suitable for analytical and in vitro applications.
- Well-defined chemical identity (CAS 61177-45-5; MW 237.25).
- Available in small research pack sizes for laboratory use.
Medchemexpress LLC Methyl 1-Cbz-azetidine-3-carboxylate | 757239-60-4 | MFCD11110708 | 99.6% | 249.26 g/mol | C13H15NO4 | 10 G
Methyl 1-Cbz-azetidine-3-carboxylate is a protected azetidine-derived building block used as a non-cleavable antibody-drug conjugate (ADC) linker and as an alkyl-chain PROTAC linker in medicinal chemistry and bioconjugation. The compound is supplied for research use only.
- High purity 99.6% (GC).
- Molecular weight 249.26 g/mol; chemical formula C13H15NO4.
- Suitable for ADC and PROTAC linker synthesis.
- Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Provided for research use only; not for human use.
Medchemexpress LLC Biotinylated covalent Btk inhibitor (CC-292) | 1202758-21-1 | 99.9% | 961.18 g/mol | C48H68N10O9S | 10 MG
CNX-500 is a biotinylated probe consisting of a covalent Bruton's tyrosine kinase (BTK) inhibitor chemically linked to biotin; it retains potent inhibitory activity (reported IC50 ≈ 0.5 nM) and is intended for target engagement and affinity-based experiments.
- Biotin tag enables affinity capture and pull-down assays.
- Covalent BTK inhibitor provides irreversible labeling of the target.
- High potency toward BTK (IC50 ~0.5 nM) for sensitive detection.
- High purity reduces off-target background.
- Suitable for biochemical and affinity-based proteomics applications.
- Stable under recommended storage conditions for long-term use.
Medchemexpress LLC Fmoc-azetidine-3-carboxylic acid | 193693-64-0 | MFCD01321018 | 99.9% | 323.35 | C19H17NO4 | 10 G
Fmoc-azetidine-3-carboxylic acid is an Fmoc-protected azetidine building block used in peptide synthesis and medicinal chemistry research. Supplied as a white to off-white solid with high chemical purity, it is suitable for incorporation of azetidine residues during solid-phase peptide synthesis or for use in linker design and small-molecule modifications. Storage recommendations and purity specifications support research and development workflows.
- Fmoc-protected azetidine building block suitable for peptide synthesis.
- White to off-white solid with high purity.
- Compatible with solid-phase peptide synthesis and linker design.
- Available in multiple pack sizes for research use.
- Stable under recommended storage conditions for powder and solution.
Medchemexpress LLC 1-Boc-azetidine-3-carboxylic acid | 142253-55-2 | MFCD01860897 | 98.3% | 201.22 g/mol | C9H15NO4 | 100 G
1-Boc-azetidine-3-carboxylic acid is a Boc-protected azetidine derivative used as a non-cleavable ADC linker and as an alkyl chain-based PROTAC linker. It is supplied as a white to off-white solid with reported high purity, and it is provided in multiple laboratory-scale pack sizes with standard storage and solubility recommendations.
- Non-cleavable ADC linker for antibody-drug conjugate synthesis.
- Suitable as an alkyl chain-based PROTAC linker.
- Appearance: white to off-white solid.
- Purity approximately 98.3% as supplied.
- Chemical formula C9H15NO4; molecular weight 201.22 g/mol.
- High solubility in DMSO (reported 100 mg/mL) and formulation protocols for in vivo use.
- Storage recommendations: powder at -20°C for long term, 4°C for shorter-term storage.