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Organic compounds that consist of a carboxylic acid with a vinyl functional group substitution; vinyl functional groups are a carbon - carbon double bond. Includes compounds that are derived from acrylic acids.
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7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells
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Etretinate (Tegison Ethyl etrinoate Retinoid Etretinato Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes It activates retinoid receptors causing an induction of cell differentiation inhibition of cell proliferation and inhibition of tissue infiltration by inflammatory cells
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Irosustat (STX64 BN83495) a tricyclic coumarin sulfamate is an orally active nonsteroid-based irreversible steroid sulfatase inhibitor with an IC50 of 8 nM
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Diroximel Fumarate (ALKS-8700) is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body
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C75 (4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid) , a more stable synthetic mimic of cerulenin, inhibits fatty-acid synthase (FAS/FASN) with an IC50 of 15.53 μM and has potential therapeutic effects in several cancer models. C75 is also a potent CPT1A activator.
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Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV) hepatitis B virus (HBV) and hepatitis C virus (HCV) potently inhibits HIV-1 (EC50 range 0 03 to 6 92 nM) and HIV-2 (EC50s ranging from 0 018 to 0 025 nM)
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Brilanestrant (GDC-0810 ARN-810 is a potent ER- binder (ER- IC50 6 1 nM ER- IC50 8 8 nM) a full transcriptional antagonist with no agonism and displays good potency and efficacy in ER- degradation (EC50 0 7 nM) and MCF-7 breast cancer cell viability (IC50 2 5 nM) assays with good selectivity over other nuclear hormone receptors
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