Organofluorides
Selleck Chemical LLC AZ 3146 S2731-50mg
AZ3146 is a selective Mps1 inhibitor with IC50 of 35 nM contributes to recruitment of CENP-E (kinesin-related motor protein) less potent to FAK JNK1 JNK2 and Kit
Selleck Chemical LLC TL13-112-E1846-1G
TL13-112 is a degrader of anaplastic lymphoma kinase (ALK) with an IC50 of 0 60 nM It demonstrates anti-proliferative activity in non-small-cell lung cancer (NSCLC) and anaplastic large cell lymphoma (ALCL) cell lines
Selleck Chemical LLC AZ 960 S2214-5mg
AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of 3 nM and 0 45 nM 3-fold selectivity of AZ960 for JAK2 over JAK3 AZ 960 induces apoptosis and growth arrest
Selleck Chemical LLC Cyclo
Cyclo(-RGDfK) TFA is the salt product of Cyclo(-RGDfK) and trifluoroacetic acid (TFA) The addition of TFA enhances stability and biocompatibility Cyclo(-RGDfK) TFA effectively targets tumor microvessels and cancer cells by specifically binding to the cell surface Integrin v 3
Selleck Chemical LLC PYR-41
PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1 with no activity at E2 PYR-41 induce apoptosis
Selleck Chemical LLC AZ 3146 S2731-1g
AZ3146 is a selective Mps1 inhibitor with IC50 of 35 nM contributes to recruitment of CENP-E (kinesin-related motor protein) less potent to FAK JNK1 JNK2 and Kit
Selleck Chemical LLC AZ 960 S2214-1g
AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of 3 nM and 0 45 nM 3-fold selectivity of AZ960 for JAK2 over JAK3 AZ 960 induces apoptosis and growth arrest
Selleck Chemical LLC Cyclo
Cyclo(RGDyK) TFA is a salt formed by the combination of Cyclo(RGDyK) and trifluoroacetate (TFA) It is an effective and selective Integrin v 3 inhibitor with a low IC50 value (e g 20 nM) Cyclo(RGDyK) TFA is of great significance in the treatment of cardiovascular diseases osteoporosis inflammation and tumors
Selleck Chemical LLC PYR-41
PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1 with no activity at E2 PYR-41 induce apoptosis
Selleck Chemical LLC PYR-41
PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1 with no activity at E2 PYR-41 induce apoptosis
Selleck Chemical LLC CY-09
CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself It is tested against the five major cytochrome P450 enzymes 1A2 2C9 2C19 2D6 and 3A4 with half maximal inhibitory concentration (IC50) values of 18 9 8 18 50 50 and 26 0 M respectively
Selleck Chemical LLC Cyclohexanecarboxylic Acid
Cyclohexanecarboxylic Acid a component of the growth stimulant naphthenic acid is the starting reagent for the synthesis of polyketide-type antibiotics Phoslactomycins
Selleck Chemical LLC MI-463
MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15 3 nM