2-Iminothiolane hydrochloride is a thiolating reagent used to introduce sulfhydryl (-SH) groups onto primary amines of proteins, peptides, and oligosaccharides, facilitating labeling, conjugation, and modification workflows.
- Converts primary amines to free sulfhydryl groups for downstream conjugation.
- Reacts efficiently at pH 7-10 to form amidine linkages while introducing thiol functionality.
- High purity minimizes side reactions and contaminants.
- Solid powder; store sealed at 4°C; in solution store -80°C (6 months) or -20°C (1 month).
- Available in lab-scale sizes suitable for research, including 1 g.