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Acetylides

Organic compounds that contain a carbon - carbon triple bond substituted with a metal in the following structure: MC≡CM, where C is carbon and M is a metal.

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1

Medchemexpress LLC Propargyl-PEG8-acid | 2055014-94-1 | 98.0% | 436.49 g/mol | C20H36O10 | 1 G
SDP

Propargyl-PEG8-acid is a polyethylene glycol (PEG) based linker bearing a terminal propargyl (alkyne) group and a carboxylic acid, used for conjugation in PROTAC and antibody-drug conjugate (ADC) synthesis.

  • Contains a terminal propargyl alkyne for click chemistry.
  • Provides a carboxylic acid handle for amide coupling.
  • Approximate molecular weight 436.49 g/mol.
  • High purity (98.0%) suitable for research applications.
  • Available in multiple pack sizes, including 1 G for lab-scale use.

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2

Medchemexpress LLC Propargyl-PEG12-OH 100mg | 1036204-61-1 | 584.69 | C27H52O13 | 100 MG
SDP

Propargyl-PEG12-OH is a PEG12-based propargyl (alkyne) linker used as a click-chemistry reagent for PROTAC synthesis and bioconjugation. It contains a terminal alkyne that undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC) to conjugate with azide-containing molecules. Supplied for research use in multiple pack sizes.

  • Contains terminal alkyne for CuAAC (click chemistry).
  • PEG12 spacer provides water solubility and conformational flexibility.
  • High purity suitable for organic synthesis and conjugation reactions.
  • Available in mg to g pack sizes for lab-scale synthesis.

ENCOMPASS_PREFERRED
3

Medchemexpress LLC Propargyl-PEG1-SS-PEG1-t-butyl ester | 1807518-78-0 | MFCD28505559 | >98.0% | 320.47 g/mol | C14H24O4S2 | 10 MG
SDP

Propargyl-PEG1-SS-PEG1-t-butyl ester is a cleavable PEG-based linker containing terminal propargyl (alkyne) groups and a disulfide bond. It is used in bioconjugation workflows such as antibody-drug conjugate and PROTAC synthesis, and as a click-chemistry handle for azide-alkyne cycloaddition.

  • Cleavable disulfide linkage allows intracellular reduction and payload release.
  • Terminal propargyl groups enable copper-catalyzed and strain-promoted click reactions.
  • High purity (>98.0%) suitable for synthetic chemistry applications.
  • Molecular weight 320.47 g/mol and formula C14H24O4S2.
  • Available in small research quantities (5 mg, 10 mg, 25 mg) for lab-scale synthesis.

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