Sphingolipids
Sigma Aldrich Fine Chemicals Biosciences Colorimetric Sphingomyelin
Sphingomyelinase (SMase) or sphingomyelin phosphodiesterase catalyzes the hydrolytic cleavage of sphingolipid to phosphocholine and ceramide a second messenger involved in multiple cellular responses including the cellular response to stress. There are at least 5 types of SMases identified which are classified according to their cation dependence cellular location and pH optima for activity and include the acidic and neutral sphingomyelinase. Neutral SMases along with the acidic SMases are thought to be major contributors to the production of ceramide in response to cellular stress.
Sigma Aldrich Fine Chemicals Biosciences Sphingomyelin chicken500MG
Sphingomyelin (SM) is a principal sphingolipid in mammalian cell membranes. Its biological functions have been studied.
Sigma Aldrich Fine Chemicals Biosciences Ceramide phosphorylethanol5MG
Ceramide phosphorylethanolamine is a phosphosphingolipid. It maintains the structural framework of the plasma membrane aids in the formation and functioning of plasma membrane lipid rafts cell signaling and transduction events. Ceramide phosphorylethanolamine modulates various cellular processes like growth differentiation apoptosis and angiogenesis.
Cayman Chemical Sphinganine (d18:0), Purity: ≥95%, CAS: 764-22-7, 50 mg
A precursor of ceramide and sphingosine; can emulate S1P in cell signaling or have opposite intracellular effects
Cayman Chemical Sphinganine (d18:0), Purity: ≥95%, CAS: 764-22-7, 5 mg
A precursor of ceramide and sphingosine; can emulate S1P in cell signaling or have opposite intracellular effects
Cayman Chemical C6 NBD dihydro Ceramide (d18:0/6:0), Purity: ≥98%, CAS: 114301-97-2, 5 mg
Structurally identical to C6 NBD ceramide, but contains a saturated bond in the C-4/C-5 position of the sphingosine backbone
Cayman Chemical C8 Ceramide-1-phosphate (d18:1/8:0) (ammonium salt), Purity: ≥90%, CAS: 474943-70-9, 10 mg
C8 ceramide-1-phosphate is a short-chain analog of the naturally occurring ceramide-1-phosphate. The effects of C8 ceramide-1-phosphate are essentially the opposite of C8 ceramide; it induces DNA synthesis and cell division. The effects of C8 ceramide-1-phosphate can be attenuated by simultaneous treatment with C2 or C8 ceramide.{5183}
Cayman Chemical C12 NBD dihydro Ceramide (d18:0/12:0), Purity: ≥98%, CAS: 474943-05-0, 5 mg
A fluorescent ceramide analog that contains a saturated bond in the C-4/C-5 position of the sphingosine backbone
Cayman Chemical BODIPY FL succinimide ester, Purity: ≥95%, CAS: 146616-66-2, 1 mg
An amine-reactive fluorescent probe; ex/em = 502/511 nm; has been used in the synthesis of protease substrates that are non-fluorescent until unquenched following proteolytic cleavage; has been used in the synthesis of a fluorescent verapamil derivative and of fluorescent inhibitors of cholesterol absorption
Cayman Chemical C16 (2'(S)-hydroxy) Ceramide (d18:1/16:0), Purity: ≥95%, CAS: 890041-50-6, 1 mg
A synthetic ceramide; has no effect on C6 glioma cell viability at concentrations up to 20 µM
Cayman Chemical C18 dihydro Ceramide-d3 (d18:0/18:0-d3), Purity: ≥99% deuterated forms (d1-d3); ≤1% d0, CAS: 2699606-99-8, 1 mg
An internal standard for the quantification of C18 dihydro ceramide by GC- or LC-MS
Cayman Chemical C8 Ceramide-1-phosphate (d18:1/8:0) (ammonium salt), Purity: ≥90%, CAS: 474943-70-9, 25 mg
C8 ceramide-1-phosphate is a short-chain analog of the naturally occurring ceramide-1-phosphate. The effects of C8 ceramide-1-phosphate are essentially the opposite of C8 ceramide; it induces DNA synthesis and cell division. The effects of C8 ceramide-1-phosphate can be attenuated by simultaneous treatment with C2 or C8 ceramide.{5183}
Cayman Chemical C12 NBD dihydro Ceramide (d18:0/12:0), Purity: ≥98%, CAS: 474943-05-0, 1 mg
A fluorescent ceramide analog that contains a saturated bond in the C-4/C-5 position of the sphingosine backbone
Cayman Chemical Sphinganine (d18:0), Purity: ≥95%, CAS: 764-22-7, 10 mg
A precursor of ceramide and sphingosine; can emulate S1P in cell signaling or have opposite intracellular effects
Cayman Chemical C26 1 Sphingomyelin-d5 d18 1
An internal standard for the quantification of C26:1 sphingomyelin by GC- or LC-MS