Glycerolipids
Medchemexpress LLC 1 2-Distearoyl-rac-g 50mg
1 2-Distearoyl-rac-glycerol is a biochemical reagent that can be used as a biological material or organic compound for life science related research
Medchemexpress LLC HY-135297 100mg Medchemexpress, Mono-and diglycerides CAS: Purity:>98%
Medchemexpress, HY-135297 100mg Mono-and diglycerides CAS: Mono-and diglycerides is formed by triglycerides being broken down by pancreatic lipase in the gastrointestinal lumen. Mono-and diglycerides is a food additive used as a nonionic emulsifier and mainly present in food fats. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC 1,2-distearoyl-3-chloropropanediol (racemic) | 72468-92-9 | MFCD18452167 | >99.0% | 643.46 g·mol⁻¹ | C39H75ClO4 | 10 MG
rac-1,2-distearoyl-3-chloropropanediol is a racemic distearoyl ester of 3-chloropropanediol used as a lipid-class biochemical reagent and analytical reference material for life-science research. It is suitable for method development, analytical testing, and studies that require defined fatty acyl esters and reproducible lipid standards.
- Lipid-class biochemical reagent suitable for analytical and research applications.
- Racemic form for studies requiring ± isomer composition.
- High purity >99.0% for reproducible analytical results.
- CAS number 72468-92-9 for unambiguous identification.
- Supplied in small pack sizes for method development and testing.
Medchemexpress LLC MI-538 | 1857417-10-7 | 98.2% | 566.60 | 1 ML
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. It is for research use only and not sold to patients.
- Inhibits menin and MLL fusion proteins interaction
- Potent cellular activity with improved binding affinity to menin
- Strong down-regulation of Hoxa9 and Meis1 genes expression
- Reduces tumor volume by approximately 80% in mice xenograft models
- Improved exposure (AUC values), Cmax, and lowest clearance
- Half-life: approximately 1.6 hours
- Oral bioavailability: approximately 50%
Medchemexpress LLC 1H-Indole-2-carbonitrile, 6-hydroxy-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluor... | 1857417-10-7 | 98.2% | 566.60 | 1 MG
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. It is for research use only and not sold to patients.
- Inhibits the proliferation of MLL leukemia cells with a GI50 of 83 nM.
- Shows selectivity towards MLL fusion protein transformed cells.
- Binds to menin with a Kd of 6.5 nM.
- Leads to strong down-regulation of Hoxa9 and Meis1 gene expression.
- Reduces tumor volume in mice xenografts.
- Improved exposure and Cmax in blood plasma.
- Low clearance and a half-life of about 1.6 hours.
- High oral bioavailability (~50%).
- Soluble in DMSO.
- Soluble in various in vivo protocols, including 10% DMSO, 40% PEG300, 5% Tween-80, 45% Saline.
Medchemexpress LLC MI-538 | 1857417-10-7 | 98.0% | 566.60 | 25 MG
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. For research use only. We do not sell to patients.
- Inhibits the proliferation of MLL leukemia cells with a GI50 of 83 nM.
- Shows selectivity toward MLL fusion protein transformed cells, with no effect (up to 6 μM) on control cell lines HL-60 and HM-2 that do not harbor MLL translocations.
- Binds to menin with low nanomolar affinity (Kd=6.5 nM).
- Potent cellular activity due to improved binding affinity to menin and possibly increased cell membrane permeability.
- Results in strong down-regulation of Hoxa9 and Meis1 gene expression.
- In vivo, it causes an approximately 80% reduction in MV4;11 tumor volume without significant toxicity.
- Demonstrates improved exposure (AUC values), Cmax, and lowest clearance in blood plasma.
- Has a half-life of about 1.6 h and high oral bioavailability (~50%).