Recombinant Proteins
Selleck Chemical LLC Silmitasertib (CX-4945) 5mg 1009820-21-6
Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Silmitasertib induces autophagy and promotes apoptosis. Phase 1/2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Phgdh-inactive | 1914971-16-6 | 99.9% | 10 MG
PHGDH-inactive is a chemically characterized negative-control compound used in biochemical and cell-based assays. It has no inhibitory activity against phosphoglycerate dehydrogenase (PHGDH) and is supplied with high reported purity for research use only.
- Negative control for PHGDH inhibitor assays.
- No activity against PHGDH.
- Reported purity 99.93%.
- Molecular weight 327.45 g/mol.
- Chemical formula C17H21N5S.
- Available as powder and as 10 mM solution in DMSO.
- For research use only; not for human or veterinary use.
![Medchemexpress LLC Benzamide, 4-[5-[(3-pyridinylmethyl)amino]pyrazolo[1,5-a]pyrimidin-3-yl]- | 2414909-94-5 | 98.2% | C19H16N6O | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261757.png-250.jpg)
Medchemexpress LLC Benzamide, 4-[5-[(3-pyridinylmethyl)amino]pyrazolo[1,5-a]pyrimidin-3-yl]- | 2414909-94-5 | 98.2% | C19H16N6O | 10MG
RET V804M-IN-1 is a small-molecule research inhibitor selective for the RET V804M mutant kinase. It shows potent activity (reported IC50 = 20 nM) and is supplied for in vitro research applications. The compound is characterized by high purity and is available as a solid or as ready-to-use DMSO solutions; analytical documentation is provided.
- Selective inhibitor of RET V804M mutant kinase (IC50 = 20 nM).
- High purity chemical suitable for research use.
- Available as dry powder and as 10 mM solutions in DMSO.
- Analytical documentation available, including COA, SDS, and data sheet.
- Chemical formula C19H16N6O; molecular weight 344.37 g·mol⁻¹.
- For research use only; not for human or diagnostic use.
Medchemexpress LLC TNF-α (10-36), human (TFA) | 98.2% | 3110.36 | 5 MG
TNF-α (10-36), human (TFA) is a research-grade laboratory chemical supplied as a white to off-white solid. With a molecular weight of 3110.36 and a purity of 98.2% by HPLC, this substance is intended for laboratory research and the manufacture of other substances by experienced personnel. It is not fully validated for medical applications.
- High purity (98.2%) confirmed by HPLC.
- Suitable for laboratory chemical applications.
- Provided as a stable solid.
- Requires sealed storage away from moisture and light.
- Long-term stability when stored as powder at -80°C for up to 2 years or -20°C for 1 year.
- Can be shipped at room temperature for durations less than 2 weeks.
Medchemexpress LLC HY-P7309 10ug Medchemexpress, TWEAK (CHO-expressed), Human CAS: Purity:>98%
Medchemexpress, HY-17420A 100mg Cyclophosphamide (hydrate) CAS:6055-19-2 Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Dnmt3a-in-1 | 1403598-56-0 | 99.9% | C30H38N6O4 | 10MG
DNMT3A-IN-1 is a selective, non-nucleoside inhibitor of DNA methyltransferase 3A (DNMT3A) supplied for research use. It inhibits DNMT3A enzymatic activity in biochemical assays and has been reported to induce apoptosis and differentiation in acute myeloid leukemia (AML) cell lines.
- Selective inhibition of DNMT3A in biochemical assays.
- Reported to induce apoptosis and differentiation in AML cell lines.
- Characterized molecular formula and molecular weight for identification.
- High chemical purity suitable for research applications.
- Available as solid or solution formats for assay flexibility.
- Provided with a product datasheet containing analytical information.
![Medchemexpress LLC (2,6-dimethoxyphenyl)-[4-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methanone | 858557-69-4 | 99.1% | 407.46 g/mol | C23H25N3O4 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000221079.png-250.jpg)
Medchemexpress LLC (2,6-dimethoxyphenyl)-[4-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methanone | 858557-69-4 | 99.1% | 407.46 g/mol | C23H25N3O4 | 5 MG
20S Proteasome-IN-1 is a small-molecule 26S proteasome inhibitor supplied as a white to off-white solid for research use. It is intended for biochemical and cellular studies relevant to cancer, inflammation, immune-related disorders, ischemia, and neurodegenerative disease research.
- High purity of 99.13%.
- Molecular weight 407.46 g/mol.
- Chemical formula C23H25N3O4.
- Solid, white to off-white appearance for easy visual inspection.
- Storage recommendations: store at 4°C; in solvent, keep at -80°C up to 6 months or -20°C up to 1 month.
- Supplied in a small-mass vial suitable for research-scale experiments.
Medchemexpress LLC N-(3,4-dimethoxy-5-(3-(4-methylpiperazin-1-yl)propoxy)phenyl)-1-(4-methoxyphenyl)-1H-pyrazolo... | 1381930-17-1 | 99.4% | 533.62 g/mol | C28H35N7O4 | 25MG
TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine small molecule that potently and selectively inhibits TBK1 and IKKε. It is used in biochemical and cellular research to probe innate immune signaling, interferon responses, and TBK1-dependent cancer phenotypes.
- Potent dual TBK1 and IKKε inhibitor (IC50: TBK1 13 nM; IKKε 59 nM).
- High chemical purity: 99.4% (HPLC).
- Molecular formula C28H35N7O4; molecular weight 533.62 g/mol.
- Physical form: white to light yellow solid; supplied as powder.
- Storage: powder -20°C for long term; in solvent -80°C for short term.
- Suitable for biochemical kinase assays and cellular studies of IFNβ signaling.
Medchemexpress LLC PILR-alpha Protein, Human (178a.a, HEK293, Fc) | ≥95.0% | 60-70 kDa | 50 UG
This human PILR-alpha protein is supplied as a lyophilized powder, suitable for laboratory chemical applications and manufacturing. Derived from HEK293 cells, it has a molecular weight of 60-70 kDa and a purity of ≥95% as determined by Tris-Bis PAGE. It is designed for research use only and should be handled by experienced personnel.
- Human PILR-alpha protein.
- Expressed in HEK293 cells.
- C-hFc tagged.
- High purity (≥95%).
- Molecular weight of 60-70 kDa.
- Provided as lyophilized powder.
- Stable for 2 years at -20°C (unreconstituted).
- Stable for 1 week at 4°C or longer at -20°C (reconstituted with carrier protein).
- Recommended for laboratory research.
Medchemexpress LLC (2S,4R)-n-((S)-3-(4-((4-(((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamoyl) | 2666951-70-6 | 99.9% | C52H59ClN6O7 | 10MG
ARD-266 is a von Hippel-Lindau (VHL) E3 ligase-based PROTAC that selectively induces degradation of the androgen receptor (AR) in AR-positive prostate cancer cell lines. The molecule includes an alkyne handle for click chemistry and is provided as a high-purity solid for preclinical research.
- VHL-based PROTAC mechanism targeting AR degradation.
- Potent activity with DC50 values of 0.2-1 nM in AR+ cell lines.
- Reduces AR protein levels by over 95% in tested cell lines.
- Contains an alkyne group enabling copper-catalyzed azide-alkyne cycloaddition.
- High chemical purity (99.94%), suitable for biological assays.
- Supplied as a white to off-white solid for handling and storage.
Medchemexpress LLC Anti-CXCL4/PF4 Antibody | 95.2% | 1 MG
The Anti-CXCL4/PF4 Antibody from MedChemExpress is a laboratory chemical designed for the manufacture of substances and intended for research use only. This product is supplied as a colorless to light yellow liquid solution and has been tested to comply with given specifications, demonstrating chemical stability under recommended storage conditions.
- Purity of 95.15% by SEC-HPLC
- Concentration of 5.90 mg/mL
- Endotoxin level is less than 1 EU/mg
- Binding activity (ELISA) of 1.248 μg/mL
- Formulated as a 0.22 μm filtered solution in 100 mM Pro-Ac, 20 mM Arg, pH 5.0
- Recommended storage at -80°C for 2 years
Medchemexpress LLC Carboxylesterase-IN-2 | 2764748-88-9 | 99.9% | 272.3 g/mol | C13H12N4OS | 5 MG
Carboxylesterase-IN-2 is a small-molecule inhibitor of the Notum/carboxylesterase family supplied for laboratory research use. It is provided as a solid and as a DMSO solution and is intended for biochemical and cellular assays studying carboxylesterase activity and related signaling pathways.
- Potent inhibitor of Notum/carboxylesterase for biochemical studies.
- High purity (99.9%) suitable for research assays.
- Chemical formula C13H12N4OS; molecular weight 272.3 g/mol.
- Available as a 5 mg solid and as a 10 mM x 1 mL DMSO solution.
- Documented analytical data available for quality verification.
Medchemexpress LLC Carboxylesterase-IN-2 | 2764748-88-9 | MFCD34676360 | 99.9% | C13H12N4OS | 10MG
Carboxylesterase-IN-2 is a small-molecule inhibitor of the carboxylesterase Notum used in research to modulate Wnt signaling and study disease biology. It is reported to be highly potent (IC50 ≤ 10 nM) and is supplied at high purity with supporting analytical and safety documents for laboratory use.
- Potent Notum inhibition (IC50 ≤ 10 nM).
- High chemical purity suitable for research applications.
- Available as solid and as a DMSO solution for convenience.
- Supplied with datasheet, certificate of analysis, and safety data sheet.
- Recommended storage: powder at -20°C; in solvent at -80°C.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Cadherin-17 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) | Approximately 95-130 kDa | 25 UG
This recombinant Cadherin-17 protein from Cynomolgus is biotinylated with a His-Avi tag and produced in HEK293 cells. It is intended for laboratory use as a chemical substance in research and manufacturing. The protein appears as a lyophilized powder and has a molecular weight of approximately 95-130 kDa due to glycosylation. It is stable under recommended storage conditions and is not considered a hazardous substance.
- Recombinant protein produced in HEK293 cells
- Biotinylated with His-Avi tag
- Molecular weight approximately 95-130 kDa
- Supplied as a lyophilized powder
- Stable under recommended storage conditions
- Suitable for laboratory research and manufacturing
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